cancer statistics in India 2022

India’s cancer statistics are recorded by the National Cancer Registry Programme (NCRP) of the National Center for Disease Informatics and Research (NCDIR), Bengaluru, an institute of the Indian Council of Medical Research (ICMR). The ICMR-NCDIR-NCRP pulls the data through 36 PBCRs (Population-based cancer registry) and 236 HBCRs (Hospital-based cancer registry). The approximate projected cases of cancer in India were 1,392,179 (~1.4 million) in the year 2020, leading to 850,000 (~0.85 million) deaths due to cancers. The five leading cancers in India, as per reported data, were breast, lung, mouth, cervix uteri, and tongue. The sex-based incidences reported were 679,421 male patients and 712,758 female patients. Breast and cervix uteri cancers were the most common cancer types in females in India. Breast cancer incidences show steady increasing reporting trends, and the majority of incidences reported are from metropolitan cities. The increasing reports of breast cancer in women pose a concern for health agencies for necessary action to control and generate necessary medical facilities. Lung, mouth, esophagus, stomach, and nasopharynx cancer are prominent in males. Lung cancer, the leading type of cancer reported in metropolitan cities, is in general agreement with the trend line of global data. The presumptive association of lung cancer with tobacco smoking and prevalent air pollution in cities is consistent with this trend. The increasing use of synthetic pesticides in agriculture has also been considered a contributing factor along with improper industrial waste disposal practices for increasing cancer cases, particularly associated with the prevalence of new cases of cancer in specific regions. The PCBRs data indicated the association of almost a third of cancer incidences with tobacco use (smoking and chewing) in India. The social norms related to avoiding tobacco use have been emphasized towards preventive measures for most cancer cases in India.

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Global Cancer Statistics 2022: the trends projection analysis

Published in Chemical Biology Letters


Also refer above article link for queries: Cancer prevalence 2022; Cancer incidences in India; Cancer prevalence in India 2022; Cancer statistics in India; report 2023; Cancer types in India; Role of pesticides in Cancer cases in India; Tobacco smoking and cancer in India; female cancer type in India; Male cancer types in India; Total case of cancer; worldwide cancer statistics 2022; world and India cancer cases and deaths; cancer deaths in India; lung cancer cases in India; breast cancer cases in India; leading cancer types in India; covid-19 and cancer; drugs for cancer; research advances in cancer;

Global Cancer Statistics 2022: the trends projection analysis

Global Cancer Statistics 2022: the trends projection analysis

Cancer is one of the most fatal diseases of recent times that causes several deaths every year. The disease variations in different parts of the world, the impact of available medical facilities, and other socio-economic factors have impacted the proper management of this disease. The comparative statistical data of cancer types like breast, prostate, colon, lung, lymph, blood, brain, and kidney cancers can be used to design treatment strategies and therapeutics development. With the advancement of science, several drugs besides diagnostic methods have emerged to control respective cancer and have assisted in curing this disease to some extent. The comparative statistics analysis for cancer about current prevalence is included here to bring a clear framework for the efforts towards future drug development to manage this disease. The availability of new diagnostics and therapeutics and advanced medical facilities in clinics impact cancer statistics. An evaluation of current trends and statistics of cancer pathology vis-à-vis theranostics (diagnostics as well as therapeutics) progress with possible application in clinical settings constitutes the core part of the discussion in this review.

URN:NBN:sciencein.cbl.2023.v10.451

Global Cancer Statistics 2022: the trends projection analysis – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/451

Chemical Biology Letters

Synthesis of new regioselective imidazole-isoxazole hybrids as in vitro antibacterial agents

Synthesis of new regioselective imidazole-isoxazole hybrids as in vitro antibacterial agents

The one-pot synthesis of some novel imidazole-isoxazole hybrids (5a-5n) and their in vitro antibacterial evaluation against Bacillus subtilis and Staphylococcus aureus was described herein. Among all, compounds 5f, 5g, 5i and 5j displayed greater zone of inhibition on Staphylococcus aureus than the standard streptomycin. Besides, compounds 5f, 5g, 5h, 5i, 5j and 5k displayed higher zone of inhibition towards Bacillus subtilis than the standard. Lastly, minimum inhibitory concentration (MIC) studies of active compounds 5f, 5g, 5h, 5i, 5j and 5k showed that the compounds 5i and 5j having lesser MIC values on Staphylococcus aureus and Bacillus subtilis than the standard.

URN:NBN:sciencein.cbl.2022.v9.425

Synthesis of new regioselective imidazole-isoxazole hybrids as in vitro antibacterial agents – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/425

Chemical Biology Letters

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies

We report the synthesis and characterization of a series of metal complexes of bivalent Cobalt, Nickel, Copper, Zinc and Palladium with novel Schiff base ligand 4-((4-isopropoxybenzylidene)amino)-5-propyl-4H-3-thiol-1,2,4-triazole (IBPT). The ligand (IBPT) was derived by the condensation reaction of 4-isopropoxybenzaldehyde and 4-amino-5-propyl-3-thiol-1,2,4-triazole and characterised by IR and proton(1H) NMR spectroscopic techniques. The complexes have been investigated using characterised Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), electron spin resonance (ESR), UV−visible and fluorescence spectroscopies. Based on the comparative analysis of IR and NMR data of ligand and metal complexes, it has been suggested that the ligand chelates with metal ions in a bidentate fashion via N (azomethine) and S (thiol) atoms. Elemental analysis, molar conductance, magnetic moments and redox behaviour of complexes have also been studied. In addition, Tauc’s formula has been employed to determine the optical bandgap of complexes using the electronic spectral data. Thermogravimetric analysis revealed the number of coordinated water molecules and thermal stability of metal complexes. Various thermodynamic and kinetic parameters have been evaluated with the help of thermal data using Coats- Redfern method. The octahedral environment of divalent Cobalt, Nickel and Zinc complexes while square planner structure of Copper and Palladium complexes was elucidated with the help of spectroscopic data. Moreover, in-vitro antimicrobial activities of Schiff base ligand and its complexes were estimated against four pathogenic bacterial (two Gram Positive, two Gram negative) and three fungal strains (C. Albicans, A. Niger and A. Clavatus). The biological outcomes ensure the convenient utility of these novel complex as antimicrobial agents.

URN:NBN:sciencein.cbl.2022.v9.407

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/407

Chemical Biology Letters

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model

Intracerebral haemorrhage is the condition of bleeding inside the brain, either spontaneous or traumatic. Though this form of stroke accounts to only about 15% of the cases, the mortality rate is the highest. People with stroke associated with ICH very rarely regain functional independence. The post-stroke complications are due to the extending loss of vascular integrity leading to prolonged secondary inflammation. Early detection of biomarkers associated with the condition and the efficacy of these biomarkers to depict the prognostic rate become essential tools for the clinicians to handle patients with ICH. Development of in vivo models that can simulate the intricate pathophysiology of the condition can add up new biomarkers that serve diagnostic and prognostic purposes.

URN:NBN:sciencein.cbl.2022.v9.408

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/408

Chemical Biology Letters

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents

The synthesis of novel 1,2,3-triazoles of Nilutamide (4a–4n) via Cu(I)-promoted 1,3-dipolar cycloaddition reaction between several terminal alkynes and 1-(3-azidopropyl)-5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione have been reported herein. In vitro anticancer activity studies of these synthesized compounds over two human prostate cell lines PC3 and DU-145 revealed that the compounds 4c, 4f and 4n exhibit slightly greater activity against two cell lines than the standard etoposide. Predominantly, the compound 4f displayed excellent activity over PC3 and DU-145 having IC50 values of 1.84and 1.34 μM respectively. The three most potent compounds 4c, 4f and 4n were also investigated for their inhibitory potential against tyrosine kinase EGFR and found that compound 4f showed superior activity than the standard erlotinib, while remaining two compounds 4c and 4n showed comparable activity with the standard.

URN:NBN:sciencein.cbl.2022.v9.405

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/405

Chemical Biology Letters

Global Cancer Statistics 2022: the trends projection analysis

Global Cancer Statistics 2022: the trends projection analysis

Cancer is one of the most fatal diseases of recent times that causes several deaths every year. The disease variations in different parts of the world, the impact of available medical facilities, and other socio-economic factors have impacted the proper management of this disease. The comparative statistical data of cancer types like breast, prostate, colon, lung, lymph, blood, brain, and kidney cancers can be used to design treatment strategies and therapeutics development. With the advancement of science, several drugs besides diagnostic methods have emerged to control respective cancer and have assisted in curing this disease to some extent. The comparative statistics analysis for cancer about current prevalence is included here to bring a clear framework for the efforts towards future drug development to manage this disease. The availability of new diagnostics and therapeutics and advanced medical facilities in clinics impact cancer statistics. An evaluation of current trends and statistics of cancer pathology vis-à-vis theranostics (diagnostics as well as therapeutics) progress with possible application in clinical settings constitutes the core part of the discussion in this review.

URN:NBN:sciencein.cbl.2023.v10.451

Global Cancer Statistics 2022: the trends projection analysis – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/451

Chemical Biology Letters

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies

We report the synthesis and characterization of a series of metal complexes of bivalent Cobalt, Nickel, Copper, Zinc and Palladium with novel Schiff base ligand 4-((4-isopropoxybenzylidene)amino)-5-propyl-4H-3-thiol-1,2,4-triazole (IBPT). The ligand (IBPT) was derived by the condensation reaction of 4-isopropoxybenzaldehyde and 4-amino-5-propyl-3-thiol-1,2,4-triazole and characterised by IR and proton(1H) NMR spectroscopic techniques. The complexes have been investigated using characterised Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), electron spin resonance (ESR), UV−visible and fluorescence spectroscopies. Based on the comparative analysis of IR and NMR data of ligand and metal complexes, it has been suggested that the ligand chelates with metal ions in a bidentate fashion via N (azomethine) and S (thiol) atoms. Elemental analysis, molar conductance, magnetic moments and redox behaviour of complexes have also been studied. In addition, Tauc’s formula has been employed to determine the optical bandgap of complexes using the electronic spectral data. Thermogravimetric analysis revealed the number of coordinated water molecules and thermal stability of metal complexes. Various thermodynamic and kinetic parameters have been evaluated with the help of thermal data using Coats- Redfern method. The octahedral environment of divalent Cobalt, Nickel and Zinc complexes while square planner structure of Copper and Palladium complexes was elucidated with the help of spectroscopic data. Moreover, in-vitro antimicrobial activities of Schiff base ligand and its complexes were estimated against four pathogenic bacterial (two Gram Positive, two Gram negative) and three fungal strains (C. Albicans, A. Niger and A. Clavatus). The biological outcomes ensure the convenient utility of these novel complex as antimicrobial agents.

URN:NBN:sciencein.cbl.2022.v9.407

Metal based bio-active 1,2,4 triazole derivatives: Preparation, spectral, thermal and antimicrobial studies – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/407

Chemical Biology Letters

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model

Intracerebral haemorrhage is the condition of bleeding inside the brain, either spontaneous or traumatic. Though this form of stroke accounts to only about 15% of the cases, the mortality rate is the highest. People with stroke associated with ICH very rarely regain functional independence. The post-stroke complications are due to the extending loss of vascular integrity leading to prolonged secondary inflammation. Early detection of biomarkers associated with the condition and the efficacy of these biomarkers to depict the prognostic rate become essential tools for the clinicians to handle patients with ICH. Development of in vivo models that can simulate the intricate pathophysiology of the condition can add up new biomarkers that serve diagnostic and prognostic purposes.

URN:NBN:sciencein.cbl.2022.v9.408

Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/408

Chemical Biology Letters

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents

The synthesis of novel 1,2,3-triazoles of Nilutamide (4a–4n) via Cu(I)-promoted 1,3-dipolar cycloaddition reaction between several terminal alkynes and 1-(3-azidopropyl)-5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione have been reported herein. In vitro anticancer activity studies of these synthesized compounds over two human prostate cell lines PC3 and DU-145 revealed that the compounds 4c, 4f and 4n exhibit slightly greater activity against two cell lines than the standard etoposide. Predominantly, the compound 4f displayed excellent activity over PC3 and DU-145 having IC50 values of 1.84and 1.34 μM respectively. The three most potent compounds 4c, 4f and 4n were also investigated for their inhibitory potential against tyrosine kinase EGFR and found that compound 4f showed superior activity than the standard erlotinib, while remaining two compounds 4c and 4n showed comparable activity with the standard.

URN:NBN:sciencein.cbl.2022.v9.405

Design and synthesis of new Nilutamide-1,2,3-triazole derivatives as in vitro Anticancer agents – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/405

Chemical Biology Letters