Novel fluorinated piperazine based-amino acid derivatives as antiplasmodial agents: Synthesis, bioactivity and computational studies

Novel fluorinated piperazine based-amino acid derivatives as antiplasmodial agents: Synthesis, bioactivity and computational studies

A library of twenty novel analogues of fluorinated, N-(3-hydroxy-1-phenyl-4-(4-phenylpiperazin-1-yl)alkyl)amides containing different amino acids were synthesized and tested for the activity against Plasmodium falciparum (Pf3D7) culture. All the tested compounds showed TC50 values >100 µM on HepG2 cells. Hit analogues 12c and 12e, displayed IC50 values in the sub-micromolar range, i.e., 0.696±0.0462 µM and 0.9377±0.0461 µM, respectively. Compounds 12c and 12e were also evaluated in combination with artemisinin, which slightly improved the activity of both the compounds with IC50 values of 0.19 µM and 0.26 µM, respectively. For compounds 12c and 12e, in-silico studies were carried out. Overall, results obtained from both in vitro and in-silico studies, indicated that 12c and 12e were hit compounds with maximum potency.

URN:NBN:sciencein.cbl.2023.v10.543

Novel fluorinated piperazine based-amino acid derivatives as antiplasmodial agents: Synthesis, bioactivity and computational studies – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/a543

Chemical Biology Letters

Dietary Polyphenolics: Mechanistic role in control management of Diabetes and Metabolic Syndrome

Dietary Polyphenolics: Mechanistic role in control management of Diabetes and Metabolic Syndrome

The search for an antidiabetic drug is going on three fronts: technological (for instance, development of an artificial pancreas), biological (such as pancreas and islet cell transplants), and pharmacological. Our review focusses on the role of polyphenolics in pharmacological research for T2DM. Being the most abundant antioxidants in human diets, dietary polyphenols have proven efficacy against a variety of diseases in both animal and human trials. Here, the authors present a review of advances in using polyphenols obtained from diet against diabetes and metabolic syndrome. Authors have discussed the role of polyphenols in disease management, and their sources. In addition to that, current knowledge of prevalent pathways of their action in cases of diabetes and metabolic syndrome have been discussed. The future directions and perspectives about diet polyphenols as a good alternative to first-line drug interventions have been included.

Dietary Polyphenolics: Mechanistic role in control management of Diabetes and Metabolic Syndrome – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/a541

Chemical Biology Letters

2023 Young Laureate (Citations) Award

The ScienceIn has instituted the authors awards for encouraging the quality contents publication by the authors. In the category, Young Laureate (Citations) Award is awarded for the relevant article published in the ScienceIN journals on achieving the good citations in a year. The 2023 Young Laureate (Citations) Award has been announced for the article

Recent development in carbon nanotubes based gas sensors

Gulshan Verma
Indian Institute of Technology Jodhpur
Ankur Gupta
Indian Institute of Technology Jodhpur

published in | Journal of Materials NanoScience  

Verma, G., & Gupta, A. (2022). Recent development in carbon nanotubes based gas sensors . Journal of Materials NanoScience, 9(1), 3–12. https://pubs.thesciencein.org/journal/index.php/jmns/article/view/282

Recent trends in synthetic Top-down approach for Mesoporous Carbon: A seminal review

This review is focused on the different synthetic methods of mesoporous carbon for exotic applications. In the 21st century, doped carbon nanostructures and composites have cutting-edge applications in materials sciences due to their superior physicochemical properties. Porous carbon has enticed material scientists because of its excellent properties like ordered porous structure, tunable pore size, and high specific surface area. As a result, the extensive studies on the synthesis and modification of mesoporous carbon are being performed. The most enticing approaches for synthesis of ordered mesoporous carbon are hard template and soft template methods. On the other hand, non-templating pathways are equally important to synthesize mesoporous carbon as that are templating pathways. This report includes details of different synthetic methods for synthesis of mesoporous carbon materials by templating as well as non-templating methods.

URN:NBN:sciencein.jmns.2023.v10.601

Recent trends in synthetic Top-down approach for Mesoporous Carbon: A seminal review – https://pubs.thesciencein.org/journal/index.php/jmns/article/view/a601

Journal of Materials NanoScience

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies

Chemical warfare agents, especially organophosphorus (OP) compounds, are known for their extreme toxicity causing inhibition of acetylcholinesterase (AChE) enzyme activity due to covalent phosphorylation. This leads to functional impairment of muscarinic nicotinic acetylcholine receptors, resulting in severe ill effects that ultimately lead to death. For OP poisoning, AChE reactivators play a crucial role in the treatment process. Among several AChE reactivators, Oxime reactivators are majorly employed for the treatment of OP intoxication, nevertheless, these are associated with certain drawbacks such as their toxic effects, low blood-brain barrier (BBB) penetration, less reactivation in the central nervous system (CNS), and inefficiency toward all nerve agents, and blocked AChE. As a result, new therapeutic strategies are required. Recent attempts are focused on the design and synthesis of uncharged oximes or non-oxime reactivators which can overcome the limitations of oxime-based reactivators. A novel class of non-oxime reactivators is gaining interest, including compounds like Mannich phenols, chloroquines, and some general bases. This review is a novel attempt to incorporate various possible oxime and non-oxime AChE reactivators for OP intoxication along with their in vitro, in vivo, and in silico studies.

URN:NBN:sciencein.cbl.2023.v10.538

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/538

Chemical Biology Letters

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis

Targeting of epidermal growth factor receptors (EGFRs) and vascular endothelial growth factor receptors (VEGFRs) has become a major strategy for the control of head and neck cancer. c-MET, a receptor tyrosine kinase is known to be expressed in many cancers including the head and neck squamous cell carcinoma (HNSCC). The c-MET activity has been correlated with many signaling pathways that help the cancer cells to proliferate, migrate and invade into the normal, healthy tissues. The association of c-MET with glycolytic pathway in HNSCC has not been elucidated yet. Since, increased glycolysis has emerged as a major hallmark for cancer cell proliferation, targeting c-MET could bring an impact to inhibit HNSCC progression. In the present study we use various In-silico tools available to identify the association of c-MET with the major metabolic genes such as HK-II (Hexokinase-II), GLUT-1 (Glucose transporter-I), LDH-A (Lactate dehydrogenase-A), PFK-II (Phosphofructokinase-II) and MCT-1 (Monocarboxylate transferase-1) in HNSCC patient datasets available from The Cancer Genome Atlas (TCGA). Protein networking analysis was used to determine the correlation of c-MET with the metabolic genes. Retrieved sequenced data pathway analysis gives the network of genes associated in the activation of glycolytic pathway. Gene ontology and Enrichr studies provide an insight into c-MET activity in metabolism through molecular, functional and pathway basis in HNSCC. Furthermore, we also have shown a negative correlation of c-MET with immune cell infiltration, suggesting c-MET might have a role in immune suppression in HNSCC patients. Further validation on this study could possibly make c-MET as a potential target to inhibit HNSCC.

URN:NBN:sciencein.cbl.2023.v10.532

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/532

Chemical Biology Letters

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol

Plants serve as an excellent source of therapeutic molecules that help in medicinal treatments. The production of large amounts of pure phytocompounds from plant sources for human consumption and the nature of phytocompounds exhibiting toxicity issues at higher dosages lead to the challenge of increasing the therapeutic effect by using low dosages. This current study focuses on extracting two active antioxidant compounds, quercetin (Q) and resveratrol (R), from plant sources and evaluating their ability to exhibit antioxidant synergism through in vitro models. Quercetin and resveratrol were extracted using an ethanol-solvent extraction procedure from Allium cepa, and Vitis vinifera peels, respectively. The extracts were subjected to qualitative and quantitative analysis, column chromatography and then High-Performance Liquid chromatography for purification. DPPH, ABTS+, SOS, and cellular antioxidant assays evaluated the synergistic antioxidant activity of the quercetin and resveratrol complex. The results showed synergistic antioxidant efficacy values approximately as follows: 5.37 % in DPPH, 15.26 % in ABTS+, 11.99 % in SOS, and 19.13 % in cellular antioxidant assays when both molecules were used combinedly. The results promisingly pave the way for a new dimension in nutraceuticals formulation parameters which could trigger combined molecular usage to achieve better results at low dosages.

URN:NBN:sciencein.cbl.2023.v10.534

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/534

Chemical Biology Letters

New Drug Delivery Review Article 2022, 2023

The drug delivery is an important factor now in rationalization of any new or existing drug towards specific ailment, the most prominently against the cancer where drug delivery systems have been extensively explored. The new advancement in drug delivery using different nano-particular systems viz. metal nanoparticles, liposomes, dendrimers, lipids, carbon nanomaterials, niosomes, phytosomes, virus, and other systems are moving towards the precision drug delivery.

All different aspects towards a precise drug delivery have been discussed in a recent review article that has been published in the ‘Applied NanoMedicine’. Readers can access the article PDF at:

The above article should also serve your queries related to drug delivery article 2023; drug delivery article 2022; new drug delivery systems; precise drug delivery; gene delivery article 2022; recent advances in drug delivery; advanced drug delivery reviews; journal article; drug delivery review PDF; Drug delivery systems updated review – PMC – NCBI; commercial drug delivery technologies; current research in drug delivery; precision nanoparticles for drug delivery – Nature; drug delivery review article; new drug delivery methods; drug delivery system pdf; drug delivery systems examples; importance of drug delivery system; Novel drug delivery system review article and related queries.

Authors can publish similar articles related to drug delivery research in the journal ‘Applied Nanomedicine‘ , the submission details, template and journal information is provided on the link

https://pubs.thesciencein.org/journal/index.php/nanomed

Journal of Molecular Chemistry – Impact factor, indexing and related matrices

Journal of Molecular Chemistry . Impact Factor*

2.4

Journal Journal of Molecular Chemistry
ISO 4J. Mol. Chem.
TypePeer Reviewed, International
Editorial BoardMultinational [Link]
DisciplineOrganic Chemistry, Catalysis, Polymers, Peptides, Macromolecules, Medicinal Chemistry, Materials Chemistry, Inorganic Chemistry, Molecule design, synthesis, and applications.
LanguageEnglish
Article typeResearch Article, Review Article,
Short Communications, Editorial

Submit your article at Journal site:
https://pubs.thesciencein.org/journal/index.php/jmc

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 4-Jan-2023

Indexed In

Google ScholarLink: https://scholar.google.com/scholar?as_vis=1&q=source:Journal+source:Molecular+source:Chemistry&hl=en&as_sdt=1,5

Google Scholar Citations : JMC on Google Scholar

Applied Nanomedicine – Impact factor, indexing and matrices info

Applied Nanomedicine Journal . Impact Factor*

4.4

Journal Applied NanoMedicine
ISO 4Appl. NanoMed.
TypePeer Reviewed, International
Editorial BoardMultinational [Link]
DisciplineNanoMedicine, Nanobiotechnology, Biomedical Nanotechnology, Nanomedical Sciences, Drug Delivery, Nanotheranostics, Nanotherapy, Nanodiagnosis, Nanopharmaceuticals
LanguageEnglish
Article typeResearch Article, Review Article,
Short Communications, Editorial

Submit your article at Journal site:
https://pubs.thesciencein.org/journal/index.php/nanomed

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 4-Jan-2023

Indexed In

Google ScholarLink: https://scholar.google.com/scholar?as_vis=1&q=source:Applied+source:Nanomedicine&hl=en&as_sdt=1,5

Google Scholar Citations : Applied Nanomedicine on Google Scholar
Nanomedicine Journal