Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition

Triazolo naphthyridines synthesis

Authors

  • Kasaboina Kalyani Priya Chaitanya (Deemed to University)
  • Kumara Swamy Jella Chaitanya deemed to be University

DOI:

https://doi.org/10.62110/sciencein.cbl.2024.v11.664

Keywords:

Naphthyridines, , Triazoles, , Anti-Microbial activity, , Microwave condition., Heterocyclic Compound

Abstract

Synthesis of 9-(4-bromophenyl)-6 aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine-2-carbonitrile (4a-j) from 7-(2-(4bromobenzylidene)hydrazinyl)-6-aryl-1,8-naphthyridine-2-carbonitrile (3) oxidized with chloramines-T in methanol under microwave irradiation is a straight forward and very efficient process. Very high yields and excellent purities of the products were achieved. Elemental analysis, IR, 1H NMR, 13C NMR and Mass spectroscopy are used to characterize the produced compounds. All synthesized compounds were tested for their antimicrobial efficacy and found moderately active against different types of bacterial and fungal strains in comparison with Streptomycin, Nystatin.

URN:NBN:sciencein.cbl.2024.v11.664

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Author Biographies

  • Kasaboina Kalyani Priya, Chaitanya (Deemed to University)

    Department of Chemistry

  • Kumara Swamy Jella, Chaitanya deemed to be University

    Department of Chemistry

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Published

2024-04-04

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URN

How to Cite

(1)
Priya, K. K. .; Jella, K. S. . Synthesis and Biological Evaluation of 1,2,4-Triazolo[4,3-a][1,8] Naphthyridines under Microwave Condition. Chem Biol Lett 2024, 11 (2), 664. https://doi.org/10.62110/sciencein.cbl.2024.v11.664.

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