Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition

Kasaboina Kalyani  Priya; Kumara Swamy  Jella

doi:10.62110/sciencein.cbl.2024.v11.664

Authors

Kasaboina Kalyani Priya Chaitanya (Deemed to University)
Kumara Swamy Jella Chaitanya deemed to be University

DOI:

https://doi.org/10.62110/sciencein.cbl.2024.v11.664

Keywords:

Naphthyridines, , Triazoles, , Anti-Microbial activity, , Microwave condition., Heterocyclic Compound

Abstract

Synthesis of 9-(4-bromophenyl)-6 aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine-2-carbonitrile (4a-j) from 7-(2-(4bromobenzylidene)hydrazinyl)-6-aryl-1,8-naphthyridine-2-carbonitrile (3) oxidized with chloramines-T in methanol under microwave irradiation is a straight forward and very efficient process. Very high yields and excellent purities of the products were achieved. Elemental analysis, IR, ¹H NMR, ¹³C NMR and Mass spectroscopy are used to characterize the produced compounds. All synthesized compounds were tested for their antimicrobial efficacy and found moderately active against different types of bacterial and fungal strains in comparison with Streptomycin, Nystatin.

URN:NBN:sciencein.cbl.2024.v11.664

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Author Biographies

Kasaboina Kalyani Priya, Chaitanya (Deemed to University)

Department of Chemistry
Kumara Swamy Jella, Chaitanya deemed to be University

Department of Chemistry