Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans

Authors

  • Sana Akhtar Usmani University of Lucknow
  • Khushboo Arya University of Lucknow
  • Basharat Ali Amity University Gurgaon
  • Shikha Chandra University of Lucknow
  • Saumya Chaturvedi University of Lucknow
  • Nitin Bhardwaj Gurukula Kangri Vishwavidyalaya, Haridwar
  • Rajendra Prasad Amity University Gurgaon
  • Ashutosh Singh University of Lucknow

DOI:

https://doi.org/10.62110/sciencein.cbl.2024.v11.658

Keywords:

Candida albicans, Lipids, Gas Chromatography, Mass Spectrometry, Azole Resistance

Abstract

Azole resistance mechanisms in Candida albicans infections majorly focus around the alteration of target enzymes, overexpression of efflux pump proteins, and changes in lipid metabolism. Our earlier lipidomic studies have linked changes in cellular lipid compositions to drug susceptibilities and phenotypic defects. This study investigates the relationship between whole cell and membrane lipid profiles in isogenic drug-susceptible and resistant isolates of C. albicans. We have examined the fatty acid and sterol snapshot lipidomics in whole cells, plasma membrane, and lipid rafts. Correlations were discovered between these lipid compositions and the observed drug resistance in C. albicans. Although the correlations drawn from cellular and plasma membrane data corroborate, understanding plasma membrane and suborganellar (rafts in this case) lipid changes may provide better insights into their roles in efflux pump activities and localization, and drug susceptibilities.

URN:NBN:sciencein.cbl.2024.v11.658

Author Biographies

  • Sana Akhtar Usmani, University of Lucknow

    Department of Biochemistry

  • Khushboo Arya, University of Lucknow

    Department of Biochemistry

  • Basharat Ali, Amity University Gurgaon

    Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology

  • Shikha Chandra, University of Lucknow

    Department of Biochemistry

  • Saumya Chaturvedi, University of Lucknow

    Department of Biochemistry

  • Nitin Bhardwaj, Gurukula Kangri Vishwavidyalaya, Haridwar

    Department of Zoology and Environmental Science

  • Rajendra Prasad, Amity University Gurgaon

    Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology

  • Ashutosh Singh, University of Lucknow

    Department of Biochemistry

membrane remodeling

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Published

2024-02-21

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Section

Articles

URN

How to Cite

Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans. (2024). Chemical Biology Letters, 11(2), 658. https://doi.org/10.62110/sciencein.cbl.2024.v11.658

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