Signaling and molecular pathways implied in oral cancer development: A concise review

oral cancer mechanism

Authors

  • Monika Kumari Deenbandhu Chhotu Ram, University of Science & Technology
  • Bhupender S. Chhikara University of Delhi
  • Priyamvada Singh University of Delhi
  • Brijesh Rathi University of Delhi
  • Geeta Singh Deenbandhu Chhotu Ram University of Science & Technology

Keywords:

Oral Cancer, Molecular Mechanism, Genes for cancer, PI3K/AKT/mTOR signaling, prognostic biomarker, NF-kB pathway, cancer signaling pathways

Abstract

Oral cancer is the sixth most prevalent type of cancer worldwide and third in India out of the different cancer types identified. Mouth and oral cancers collectively refer to cancers of the buccal cavity, lips, oropharynx, hypopharynx, and larynx. Genetic anomalies, the upregulation of several proteins, the deregulation of tumor-suppressive and oncogenes, and risk factors like alcohol and tobacco consumption are a few examples of the known irregularities that contribute to the development of oral cancer through the accumulation of various carcinogenic substances. Oral cancer is caused and developed by multiple molecular and cellular pathways such as PI3K/AKT/mTOR, Ras-Raf-MEK-ERK pathway, Wnt signaling, NF-κB pathway, Hippo pathway, etc. In addition, various genes including TP53, PTEN, CDKN2A, HRAS, PIK3CA, NOTCH1, IRF6, TP63, etc. are also involved in this malignancy. Therefore, it is crucial to have a deep understanding of these pathways to properly understand the development of oral cancer. This concise review focuses on compiling together various signaling and molecular pathways accountable for oral carcinoma development.

URN:NBN:sciencein.cbl.2024.v11.652

Author Biographies

Monika Kumari, Deenbandhu Chhotu Ram, University of Science & Technology

Department of Biomedical Engineering

Bhupender S. Chhikara, University of Delhi

Department of Chemistry, Aditi Mahavidyalaya

Priyamvada Singh, University of Delhi

Department of Chemistry, Miranda House

Brijesh Rathi, University of Delhi

Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College

Geeta Singh, Deenbandhu Chhotu Ram University of Science & Technology

Department of Biomedical Engineering

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Published

2023-11-02

How to Cite

Kumari, M., Chhikara, B. S., Singh, P., Rathi, B., & Singh, G. (2023). Signaling and molecular pathways implied in oral cancer development: A concise review. Chemical Biology Letters, 11(1), 652. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/a652

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Section

Review Articles

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