Molecular links between metabolome and epigenome: AMPK-TET2 signalling pathway and their natural activators

link between diabetes and cancer


  • Shivprasad Suresh Patil University of North Carolina, Greensboro
  • Rohit Sharma Shoolini University
  • Upendra Sharma CSIR-Institute of Himalayan Bioresource Technology
  • Yogendra Padwad CSIR-Institute of Himalayan Bioresource Technology


hyperglycemia, Diabetes, Cancer, AMPK, TET2, Natural products


Emerging evidence suggests that sustained diabetes-associated factors such as inflammation, hyperinsulinemia, and hyperglycemia are major contributors to aberrant cell proliferation and subsequent neoplastic transformation. Epidemiological studies have also highlighted that diabetes promoting a sedentary lifestyle, with or without the direct involvement of insulin, is frequently linked to cancer. However, our knowledge regarding the molecular mechanisms that correlate hyperglycemia to oncogenic transformations remains limited. In this regard, a recent study has proved that hyperglycemia inactivates AMPK, destabilizing the TET2 and its tumour-suppressive role and ultimately predisposing diabetes mellitus patients to cancer. We must explore a reverse pharmacology-based ethnopharmacological approach to managing hyperglycemia associated with oncogenesis. Botanical-derived natural products have greater structural and functional diversity with fewer or no side effects on humans. The present review discusses the molecular relationship between hyperglycemia and cancer progression and the impact of natural products as therapeutic agents on the hyperglycemia-cancer-associated signaling pathway.



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Author Biographies

  • Shivprasad Suresh Patil, University of North Carolina, Greensboro

    Center for Translational Biomedical Research

  • Rohit Sharma, Shoolini University

    Animal Biotechnology Lab

  • Upendra Sharma, CSIR-Institute of Himalayan Bioresource Technology

    Chemical Technology Division

  • Yogendra Padwad, CSIR-Institute of Himalayan Bioresource Technology

    Dietetics and Nutritional Technology Division






Review Articles


How to Cite

Patil, S. S.; Sharma, R.; Sharma, U.; Padwad, Y. Molecular Links Between Metabolome and Epigenome: AMPK-TET2 Signalling Pathway and Their Natural Activators. Chem Biol Lett 2023, 10 (3), 552.

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