Use of Tyrosine Kinase Inhibitors for treating Type 2 Diabetes Mellitus: An appraisal

Authors

  • Kunika Saini
  • Smriti Sharma University of Delhi

Keywords:

Kinases, diabetes, src kinase, kinase diabete drugs, small molecule drugs

Abstract

Tyrosine Kinase enzymes are known to play a significant role in tumor cell proliferation, stimulation of angiogenesis and metastasis and also show antiapoptotic effects. Therefore, Tyrosine Kinase inhibitors (TKIs) have been traditionally used to cure cancer. However, recently, there has been lot of interest in the possible use of TKIs for developing a new line of therapy for Type 2 Diabetes Mellitus (T2DM). Here, the authors have tried to summarize the seminal studies establishing the possible use of TKIs for T2DM. Authors conclude that there is lot of evidence suggesting the potential application of TKIs for treating T2DM, however, this hypothesis is still in its infancy stage. The animal models show promising results but there is an urgent need for detailed clinical investigations to establish this connection.

Author Biography

  • Smriti Sharma, University of Delhi

    Department of Chemistry
    Miranda House

kinase diabetes connection

Published

2022-03-22

Issue

Section

Review Articles

How to Cite

Use of Tyrosine Kinase Inhibitors for treating Type 2 Diabetes Mellitus: An appraisal. (2022). Chemical Biology Letters, 9(3), 320. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/320

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