Plant-derived bioactive compounds in Neuroblastoma therapeutics: Current outlook and future perspective

Neuroblastoma drugs from plants

Authors

  • Nidhi Goswami University of Delhi
  • Pallavi Sethi University of Delhi
  • Amar Jyoti University of Delhi
  • Garima Nagar University of Delhi
  • Shradheya R.R. Gupta University of Delhi
  • Archana Singh University of Delhi
  • Indrakant K. Singh University of Delhi

Keywords:

Phytochemicals, Neuroblastoma, Molecular signaling, Chemotherapy, Indian medicinal plants, Cancer, anti-cancer drugs, Signaling Pathway, Curcumin, Quercetin, Alkaloids, Taxanes, Podophyllotoxin, Camptothecin

Abstract

Across the globe, neuroblastoma is responsible for around 15% of child deaths. The cell signaling alterations associated with the disease often result in redundancy and tumor relapse. A plethora of chemotherapeutics, which are already available in the market, are repurposed to treat it. However, they show limited to no efficacy, giving less relief to patients. Systemic toxicities associated with drugs are often linked with comorbidities and result in their discontinuation in clinical settings. Phytochemicals, on the other hand, have come up as an alternative, with the benefits of chemopreventives and fewer side effects. Many preclinical studies using plant-derived compounds have reported molecular targets that suppress neuroblastoma growth with less toxicity. The efficacy of phytochemicals in human trials has led to their approval in clinics. India, being a rich source of biodiversity, inhabits around 11.4% of the floral population of the world. The biologically active compounds extracted from the plants grown in the Indian subcontinent have exhibited high medicinal properties since time immemorial. Our work provides insight into potential phytochemicals, obtained from Indian plants, that can be used to target molecular alterations in neuroblastoma. Besides, Measures to overcome the side effects and low bioavailability of these phytochemicals have also been discussed here.

URN:NBN:sciencein.cbl.2022.v9.400

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Author Biographies

  • Nidhi Goswami, University of Delhi

    Neuropharmacology and Drug Delivery Laboratory, Department of Zoology, Daulat Ram College, University of Delhi, Delhi-110007, India

  • Pallavi Sethi, University of Delhi

    Neuropharmacology and Drug Delivery Laboratory, Department of Zoology, Daulat Ram College, University of Delhi, Delhi-110007, India

  • Amar Jyoti, University of Delhi

    Neuropharmacology and Drug Delivery Laboratory, Department of Zoology, Daulat Ram College, University of Delhi, Delhi-110007, India

  • Garima Nagar, University of Delhi

    Molecular Biology Research Lab. Department of Zoology, Deshbandhu College, University of Delhi, Delhi-110019, India

  • Shradheya R.R. Gupta, University of Delhi

    Molecular Biology Research Lab. Department of Zoology, Deshbandhu College, University of Delhi, Delhi-110019, India

  • Archana Singh, University of Delhi

    Department of Botany, Hansraj College, University of Delhi, Delhi-110007, India

  • Indrakant K. Singh, University of Delhi

    Molecular Biology Research Lab. Department of Zoology, Deshbandhu College, University of Delhi, Delhi-110019, India

Published

2022-09-25

Issue

Section

Review Articles

URN

How to Cite

(1)
Goswami, N.; Sethi, P.; Jyoti, A.; Nagar, G.; Gupta, S. R.; Singh, A.; Singh, I. K. Plant-Derived Bioactive Compounds in Neuroblastoma Therapeutics: Current Outlook and Future Perspective. Chem Biol Lett 2022, 9 (4), 400.

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