Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents

Abstract

Hydroxyethylamine (HEA) based small molecules have extensively been evaluated for their antimalarial properties. HEA scaffold enabled generation of numerous chemical libraries with significant antimalarial activity. Besides, the tetrahedral HEA scaffold has been explored for the construction of inhibitors of malarial aspartic proteases, plasmepsin 1 and 2. This review deals with chemistry and evaluation of HEA based small molecules as antimalarial agents.