The role of Pesticides in Cancer initiation and progression: A comprehensive review

Abstract

Pesticides play a significant role in agriculture globally, yet concerns over their potential carcinogenicity have sparked scrutiny. This review discusses the complex nexus between pesticides and cancer, explaining their classification, properties, and carcinogenic mechanisms. Understanding their diverse chemical structures and modes of action is foundational. Carcinogenicity involves intricate genetic, epigenetic, and cellular pathways, highlighting their capacity to instigate and propagate cancer. Stringent regulatory measures are imperative to safeguard public health and the environment, making risk assessment and mitigation strategies unavoidable. Factors such as exposure levels, duration, and individual susceptibility underscore the multifaceted nature of pesticide-induced carcinogenesis. Pesticides influence crucial cell signaling pathways, implicating them in cellular homeostasis and aberrant proliferation. Interdisciplinary collaborations and innovative technologies are pivotal for advancing our comprehension of pesticide-cancer interactions. Addressing research gaps holds promise for developing targeted interventions and regulatory frameworks to mitigate pesticide-related cancer risks. This review offers a comprehensive synthesis of current knowledge and outlines future avenues for research and intervention strategies in pesticide-induced cancer.

URN:NBN:sciencein.cbl.2024.v11.669