Association of C-peptide with novel hormones in children with type 1 diabetes: A rising potentials for more reliable biomarkers.

diabetes biomarkers C-peptide

Authors

Keywords:

Diabetes, C-peptide, Preptin, Irisin, Biomarkers

Abstract

Type 1 diabetes is a heterogeneous disorder caused by reduced β-cell mass as a result of T-cell mediated autoimmune destruction. C-peptide is a linker chain cleaved from proinsulin to produce the mature, functional insulin hormone. Irisin is a novel adipo-myokine plays a crucial role in glucose homeostasis regulation. Preptin is a peptide hormone synthesized in β-cells and plays a role in augmenting insulin secretion. The current study aims to investigate preptin and irisin levels in diabetic children and determine their correlation with C-peptide and the development of this disease. This study recruited 90 children, divided into two groups: 45 patients and 45 controls. Commercial ELISA kits were used to measure C-peptide, irisin, and preptin. C-peptide levels were significantly decreased among the patients’ group (P<0.05). Preptin and irisin levels were significantly increased in the patients’ group (P<0.05). C-peptide was noticeably correlated with preptin, irisin and RBS (P <0.05). Preptin and irisin levels also had a positive correlation with RBS (P<0.05). In regression analysis, irisin had a strong association with C-peptide. In conclusion, irisin was a considerable predictive marker for the residual β-cells through its association with preptin and C-peptide in regression analysis. Preptin might be an indicator of insulin resistance.

URN:NBN:sciencein.cbl.2023.v10.551

Author Biographies

Zeena Amer Ajam, University of Babylon

Department of Biochemistry, College of Medicine

Seenaa Badr Mohammed, University of Babylon

Department of Biochemistry, College of Medicine

Rihab Faisal Alabedi, University of Babylon

Pediatric Department, College of Medicine

Downloads

Published

2023-06-21

How to Cite

Ajam, Z. A., Mohammed, S. B., & Alabedi, R. F. (2023). Association of C-peptide with novel hormones in children with type 1 diabetes: A rising potentials for more reliable biomarkers. Chemical Biology Letters, 10(3), 551. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/a551

Issue

Section

Articles

URN