Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model
Keywords:Zebrafish, Intracerebral hemorrhage, secondary inflammation, microglia, biomarkers, GFAP, S100B, Pentraxin 3, Cystatin C, animal model, brain, haemorrhage
Intracerebral haemorrhage is the condition of bleeding inside the brain, either spontaneous or traumatic. Though this form of stroke accounts to only about 15% of the cases, the mortality rate is the highest. People with stroke associated with ICH very rarely regain functional independence. The post-stroke complications are due to the extending loss of vascular integrity leading to prolonged secondary inflammation. Early detection of biomarkers associated with the condition and the efficacy of these biomarkers to depict the prognostic rate become essential tools for the clinicians to handle patients with ICH. Development of in vivo models that can simulate the intricate pathophysiology of the condition can add up new biomarkers that serve diagnostic and prognostic purposes.