Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model

Zebrafish as model for brain inflammations

Authors

  • Madhan Kumar Srinivasan Sri Ramachandra Institute of Higher Education and Research
  • Lalitha Vaidyanathan Sri Ramachandra Institute of Higher Education and Research

Keywords:

Zebrafish, Intracerebral hemorrhage, secondary inflammation, microglia, biomarkers, GFAP, S100B, Pentraxin 3, Cystatin C, animal model, brain, haemorrhage

Abstract

Intracerebral haemorrhage is the condition of bleeding inside the brain, either spontaneous or traumatic. Though this form of stroke accounts to only about 15% of the cases, the mortality rate is the highest. People with stroke associated with ICH very rarely regain functional independence. The post-stroke complications are due to the extending loss of vascular integrity leading to prolonged secondary inflammation. Early detection of biomarkers associated with the condition and the efficacy of these biomarkers to depict the prognostic rate become essential tools for the clinicians to handle patients with ICH. Development of in vivo models that can simulate the intricate pathophysiology of the condition can add up new biomarkers that serve diagnostic and prognostic purposes.

URN:NBN:sciencein.cbl.2022.v9.408

Author Biographies

Madhan Kumar Srinivasan, Sri Ramachandra Institute of Higher Education and Research

Department of Biomedical Sciences 

Lalitha Vaidyanathan, Sri Ramachandra Institute of Higher Education and Research

Department of Biomedical Sciences,
Sri Ramachandra Institute of Higher Education and Research,
Chennai, Tamil Nadu, India

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Published

2022-09-22

How to Cite

Srinivasan, M. K., & Vaidyanathan, L. (2022). Exploring biomarkers associated with secondary inflammation following intracerebral hemorrhage using adult Zebrafish model. Chemical Biology Letters, 9(4), 408. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/408

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Section

Review Articles