Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air

Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.

Published in: Chemical Biology Letters

Johnson, J. P., Renganthan, S., Menon, A., & Pillai, R. G. (2021). Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air. Chemical Biology Letters, 8(1), 1–9. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/158

Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor

One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora, an abundant green alga in eastern Indonesia. The result showed that ethanol and ethyl acetate extract of Bornetella oligospora contained phytochemical components such as flavonoid, glycoside, triterpenoid, and steroid. The thin layer chromatography test showed ethanol extract have five spots with Rf 0.545, 0.527, 0.5, 0.473, and 0.154, while the ethyl acetate extract has two spots with Rf 0.58 and 0.64. The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. In conclusion, Bornetella oligospora extract has the potential as an antidiabetic agent.

Published in Chemical Biology Letters

Siswanto, M. A., Paramita, R. I., Fadilah, F., & Poerwaningsih, E. H. (2021). Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor. Chemical Biology Letters, 8(1), 40–44. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/120

Biosensors for Detecting Imbalances of Life Systems: Role of Materials and Methods in Improved Outcome

Special issue on Biosensors: materials and methods
Lead 20 program

Any deviation or imbalance from homeostatic state of steady internal physical and chemical conditions in living systems, generally falls under category of disease. Chances of bringing them back to normalcy or closer to healthier state with therapeutic interventions are found to be more successful when they are applied at very early stage. Biosensing has emerged as a process to achieve early detection of deviations in such homeostatic states via evaluation of physiological, chemical, or biomolecular parameters in the subjects. The two main components on which efficiency of biosensors rely are materials used as platform technology and methods of detection used for the task. In this issue we will be assembling recent advancements in the field of Biosensors in terms of used materials and methods in achieving high sensitivity, specificity and predictability in form of original research.

Topic Editor

Santosh Misra, Ph.D.
Dept of Biological Sciences & Bioengineering,
Indian Institute of Technology,
IIT Kanpur, U.P., IN

Schedule – The dates

Abstract Submission: September 30, 2021
Article Submission: January 31, 2022 (Processing – ‘as we go’ model)
Issue completion: May 30, 2022

 
Field – Research area
Biosensors
NanoMedicine & Biomaterials
NanoChemistry and Chemistry Materials
NanoScience Nanotechnology
Polymer and Functional Materials
Materials Science

Participating Journal

Journal of Materials NanoScience – Nanomedicine section

Program

This special issue is under the Lead 20 program where leading scientists/academicians in the above field with well established lab, good publication record (an online link in form is required) and are under the age of 40 will be eligible to participate in this compilation. The editor will choose the best leading scholars from all the submitted entries (selection will be at abstract submission level as well as at full article level through peer review.

Authors / Abstracts

This is new recent Topic announced, the list of authors/abstracts will be updated here. This is an open invitations for interested researchers to submit the abstract for this topic. Submit the abstract with detail below:

The abstract details can also be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org

Immunoendocrine regulation of energy homeostasis and male reproduction

Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

Potential topics include but are not limited to the following:

  • Energy homeostasis  and male reproduction
  • Immunoendocrine regulation of male reproductive functions
  • Adipokines and energy metabolism in male fertility
  • Obesity and male infertility: energy imbalance to inflammation
  • Endocrine regulation of epigenetics of reproductive tract inflammation
  • Altered energy metabolism and immune regulation in aged men
Submission Deadline30th June 2021 15th July 2021
Publication Date1st Sept 2021

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
[pallav@mahsa.edu.my; pallav_cu@yahoo.com]
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University
[duttasulagna@mahsa.edu.my; sulagna_dutta11@yahoo.com]

Submission

Article (Research articles and Review Articles) should be submitted online on the journal site http://www.pubs.thesciencein.org/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

Clinical and Pre-Clinical advances in Medicinal Chemistry – Special Issue Chemical Biology Letters

The medicinal Chemistry, the science concerned with development of new drug molecules, has produced many new drug entities recently which has reached in the clinical trial stages of evaluation. This special issue is meant to cover the research advances in development of new drug molecules and science behind it (including molecular modeling and pharmaceutical science) along with the research advances with new molecules that has shown promising potential to move to clinical applications.

Medicinal Chemistry fraternity is invited to submit their manuscript (Research Articles, Review Articles, and Short Communications) for publication in the special issue.

Issue Editors:

Dr. Brijesh Rathi,
Associate Editor
Department of Chemistry, Hansraj College,
University of Delhi, Delhi-110007. India
Visiting Assistant Professor, Department of Chemistry
Massachusetts Institute of Technology (M.I.T.)
77 Massachusetts Ave. Cambridge, MA 02139, USA EB,
Dr. Poonam,
(Assistant Editor: Medicinal Chemistry)
Department of Chemistry, Miranda House
University of Delhi New Delhi, India

Submission

Article (Research articles and Review Articles) should be submitted online on the journal site http://www.pubs.thesciencein.org/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

Submission Deadline October 16, 2021
Issue Publication November 30 , 2021

There is no publication charges for publishing in special issue or in Chemical Biology Letters.

Editor recommended quality articles will be published with Diamond Open Access.

https://pubs.thesciencein.org/journal/index.php/cbl

Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?

Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating type 2 diabetes. In this review, authors have summarized the physiological actions of Glucagon-like peptide-1 receptor (GLP-1R) and current available drugs based on GLP-1 RAs. Some of the exemplary studies in this area have been examined in detail. Authors conclude that development of degradation-resistant, long-acting GLP-1 receptor agonists is a promising area of research and lot of work needs to be done to understand its mechanism of action.

Published in: Chemical Biology Letters

Link: https://pubs.thesciencein.org/journal/index.php/cbl/article/view/132

Chemical libraries targeting Liver Stage Malarial infection

urn:nbn:sciencein.cbl.2019v6.96

Chemical Scaffolds Targeting liver-stage malaria parasite lifecycle

Published in: Chemical Biology Letters

  • Neha Sharma
  • Poonam FNU
  • Prakasha Kempaiah
  • Brijesh Rathi University of Delhi

Keywords: Malaria, Liver stage, Primaquine, Atovaquone, Clinical trials

Abstract

Despite the noteworthy advances in the use of chemotherapy for malaria, it continues to constantly affect large number of individuals. New molecules capable of blocking life-cycle of the parasite, preferably through targeting novel pathways and various modes of action, are increasingly becoming area of interest. Phenotypic screening of large chemical libraries is certainly one of the important criteria for the discovery of new and effective drugs. In recent years, diverse research groups including pharmaceutical industries have performed this large-scale phenotypic screening to identify the potential drug molecules. Most of the antimalarial drugs target blood-stage malarial infection and remain either less potent or ineffective against other life stages i.e. liver-stage, and the gametocyte stages of the parasite. Although, liver stage is considered as a crucial drug target, limited clinical options have significantly hampered the discovery of effective treatments. This short review presents the collection of selective molecules targeting specifically liver stage malaria parasites.

Cite as: Sharma, N., FNU, P., Kempaiah, P., & Rathi, B. (2019). Chemical libraries targeting Liver Stage Malarial infection. Chemical Biology Letters, 6(1), 14-22.

Retrieved full text from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/41