Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.
One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora, an abundant green alga in eastern Indonesia. The result showed that ethanol and ethyl acetate extract of Bornetella oligospora contained phytochemical components such as flavonoid, glycoside, triterpenoid, and steroid. The thin layer chromatography test showed ethanol extract have five spots with Rf 0.545, 0.527, 0.5, 0.473, and 0.154, while the ethyl acetate extract has two spots with Rf 0.58 and 0.64. The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. In conclusion, Bornetella oligospora extract has the potential as an antidiabetic agent.
Special issue on Biosensors: materials and methods
Lead 20 program
Santosh Misra, Ph.D. Dept of Biological Sciences & Bioengineering, Indian Institute of Technology, IIT Kanpur, U.P., IN
Schedule – The dates
Abstract Submission: September 30, 2021 Article Submission: January 31, 2022 (Processing – ‘as we go’ model) Issue completion: May 30, 2022
Field – Research area Biosensors NanoMedicine & Biomaterials NanoChemistry and Chemistry Materials NanoScience Nanotechnology Polymer and Functional Materials Materials Science
This special issue is under the Lead 20 program where leading scientists/academicians in the above field with well established lab, good publication record (an online link in form is required) and are under the age of 40 will be eligible to participate in this compilation. The editor will choose the best leading scholars from all the submitted entries (selection will be at abstract submission level as well as at full article level through peer review.
Authors / Abstracts
This is new recent Topic announced, the list of authors/abstracts will be updated here. This is an open invitations for interested researchers to submit the abstract for this topic. Submit the abstract with detail below:
The abstract details can also be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org
Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.
This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.
Potential topics include but are not limited to the following:
Energy homeostasis and male reproduction
Immunoendocrine regulation of male reproductive functions
Adipokines and energy metabolism in male fertility
Obesity and male infertility: energy imbalance to inflammation
Endocrine regulation of epigenetics of reproductive tract inflammation
Altered energy metabolism and immune regulation in aged men
30th June 2021 15th July 2021
1st Sept 2021
Pallav Sengupta, PhD Department of Physiology Faculty of Medicine & Biomedical Sciences MAHSA University [firstname.lastname@example.org; email@example.com]
Sulagna Dutta, PhD Department of Physiology Faculty of Dentistry MAHSA University [firstname.lastname@example.org; email@example.com]
The medicinal Chemistry, the science concerned with development of new drug molecules, has produced many new drug entities recently which has reached in the clinical trial stages of evaluation. This special issue is meant to cover the research advances in development of new drug molecules and science behind it (including molecular modeling and pharmaceutical science) along with the research advances with new molecules that has shown promising potential to move to clinical applications.
Medicinal Chemistry fraternity is invited to submit their manuscript (Research Articles, Review Articles, and Short Communications) for publication in the special issue.
Dr. Brijesh Rathi, Associate Editor Department of Chemistry, Hansraj College, University of Delhi, Delhi-110007. India Visiting Assistant Professor, Department of Chemistry Massachusetts Institute of Technology (M.I.T.) 77 Massachusetts Ave. Cambridge, MA 02139, USA EB,
Dr. Poonam, (Assistant Editor: Medicinal Chemistry)
Department of Chemistry, Miranda House
University of Delhi New Delhi, India
Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating type 2 diabetes. In this review, authors have summarized the physiological actions of Glucagon-like peptide-1 receptor (GLP-1R) and current available drugs based on GLP-1 RAs. Some of the exemplary studies in this area have been examined in detail. Authors conclude that development of degradation-resistant, long-acting GLP-1 receptor agonists is a promising area of research and lot of work needs to be done to understand its mechanism of action.
Despite the noteworthy advances in the use of chemotherapy for malaria, it continues to constantly affect large number of individuals. New molecules capable of blocking life-cycle of the parasite, preferably through targeting novel pathways and various modes of action, are increasingly becoming area of interest. Phenotypic screening of large chemical libraries is certainly one of the important criteria for the discovery of new and effective drugs. In recent years, diverse research groups including pharmaceutical industries have performed this large-scale phenotypic screening to identify the potential drug molecules. Most of the antimalarial drugs target blood-stage malarial infection and remain either less potent or ineffective against other life stages i.e. liver-stage, and the gametocyte stages of the parasite. Although, liver stage is considered as a crucial drug target, limited clinical options have significantly hampered the discovery of effective treatments. This short review presents the collection of selective molecules targeting specifically liver stage malaria parasites.
Cite as: Sharma, N., FNU, P., Kempaiah, P., & Rathi, B. (2019). Chemical libraries targeting Liver Stage Malarial infection. Chemical Biology Letters, 6(1), 14-22.