Synthesis and biological evaluation of Trifluoromethoxyphenyl Indole Carboxamide analogs, ADME and toxicity prediction

Baban Mohan Mulik; Noopur Srivastava; Dhananjay Pendharkar

doi:10.62110/sciencein.cbl.2024.v11.660

Authors

Baban Mohan Mulik Sharda University
Noopur Srivastava Sharda University
Dhananjay Pendharkar Integral Biosciences Pvt Ltd, Noida

DOI:

https://doi.org/10.62110/sciencein.cbl.2024.v11.660

Keywords:

Anticancer, Molecular docking study, Leukemia, Indole Carboxamide, heterocyclic drugs

Abstract

We report synthesis, ADME profile, and biological evaluation of new analogues as effective Anticancer Agents. Trifluoromethoxyphenyl indole-5-carboxamide analogues (4a-4m) were developed as a class of strong inhibitors of BCR-ABL1 kinase. The compounds (4c, 4e, and 4m) showed good anticancer activity in cancer cell lines such as MCF7, MV411 and K562 with IC50 values of 1.4 µM, 1.7 µM, and 1.1 µM, respectively. In human liver microsomes, these substances likewise displayed a favorable ADME profile, good solubility, and minimal clearance. In an oncology program these analogues offer a promising beginning for the development of BCR-ABL1 kinase inhibitors.

URN:NBN:sciencein.cbl.2024.v11.660

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Author Biographies

Baban Mohan Mulik, Sharda University

Department of Chemistry and Biochemistry
Noopur Srivastava, Sharda University

Department of Chemistry and Biochemistry, Sharda School of Basic Sciences & Research (SSBSR)