Category: Readings
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Epitope-based Vaccine development: A detailed overview from in-silico vaccine design to wet lab validation
Epitope-based Vaccine development: A detailed overview from in-silico vaccine design to wet lab validation In-silico epitope-based vaccine is the cornerstone of modern vaccine development and is illuminating by a growing number of experimental and computational methods. The reverse vaccinology approach uses computational screening of the whole proteome of a pathogen to identify the proteins with…
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Pioglitazone and Ezetimibe combination improves Liver histopathology and biochemistry in experimental MASH models
Pioglitazone and Ezetimibe combination improves Liver histopathology and biochemistry in experimental MASH models Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are common clinico-pathological conditions that affecting over 30% of adults worldwide. Insulin resistance and hepatic lipid accumulation constitute the metabolic foundation of MASLD/MASH. Although previous studies have shown limited efficacy of…
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Cu and Zn based nanoparticles for degradation of dyes by Advanced Oxidation Process.
Every year thousand tons of synthetic dyes are discharged into water bodies from cosmetics, textile, plastics, leather, and food processing industries. It generates million tons of wastewater. Rising environmental concerns and awareness necessitates removal of dyes from the industry water which became a crucial need for the betterment of the environment. However, many dyes are…
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Biological and electrochemical Sensor detection studies of ZrO2 wrapped by reduced Graphene Oxide nanocomposite
The present work reports synthesis of ZrO2 nanoparticles wrapped by reduced graphene doped (rGO) nanosheet through simple reflux method. The sample was characterized using XRD, FE-SEM, EDAX, FTIR, UV-Visible techniques. The optical bandgap was calculated using Tauc’s method and found to be ZrO2 and ZrO2/rGO are 1.47 and 1.25 eV, respectively. The prepared rGO/ZrO2 was…
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Sodium ion (Na+) batteries – a comprehensive review
Sodium-ion batteries (SIBs) have emerged as a promising alternative to lithium-ion batteries (LIBs) due to the abundant availability and low cost of sodium. Recent advances in SIB technology have focused on enhancing the performance, safety, and cost-effectiveness of these batteries. Significant progress has been made in the development of high-capacity anode and cathode materials, including…
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Acetamiprid exposure causes molecular and structural changes in the liver and kidney tissues of rats
Acetamiprid exposure causes molecular and structural changes in the liver and kidney tissues of rats Pesticides are among the most widely used synthetic chemicals worldwide to protect crops, but they pose several environmental and health issues. The present study evaluates toxic effects of acetamiprid (ACMP) in rat liver and kidney tissues. Rats were exposed to…
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A novel Fusion-5 Filter based Micro-chip: A highly efficient, On-chip DNA extraction and On-chip PCR amplification for rapid detection
A novel Fusion-5 Filter based Micro-chip: A highly efficient, On-chip DNA extraction and On-chip PCR amplification for rapid detection A novel, sensitive, portable method for detecting DNA from various human samples is most desirable. This study aims to develop a microdevice for on-chip DNA extraction and detection by PCR from various forensic samples. A microchip…
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ASETSD-Advances in Science, Engineering & Technology for Sustainable Development (ASETSD)
A special issue on Advances in Science, Engineering & Technology for Sustainable Development (ASETSD) covering the chemical sciences, chemical biology, chemical engineering, green synthesis, biomass derived chemicals, nanotechnology, chemical sensors, photochemical reactions, green fuels, natural products, environmental chemistry, Biomedical Technology, and Mathematical Modeling and Computational Techniques towards advances & sustainability.
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DNA-protein crosslinks are key to platinum-based chemotherapeutic cytotoxicity
DNA-protein crosslinks are key to platinum-based chemotherapeutic cytotoxicity Platinum-based chemotherapeutics inflict a spectrum of DNA damage, including DNA adducts, DNA-protein crosslinks (DPCs), and interstrand crosslinks (ICLs) to variable extents. These diverse lesions may contribute to the overall toxicity of these therapeutic agents. Nonetheless, a gap exists in comparative studies elucidating the specific DNA damage responsible…
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Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition
Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition Synthesis of 9-(4-bromophenyl)-6 aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine-2-carbonitrile (4a-j) from 7-(2-(4bromobenzylidene)hydrazinyl)-6-aryl-1,8-naphthyridine-2-carbonitrile (3) oxidized with chloramines-T in methanol under microwave irradiation is a straight forward and very efficient process. Very high yields and excellent purities of the products were achieved. Elemental analysis, IR, 1H NMR, 13C NMR and Mass spectroscopy…