Recent advances in Mass Spectrometry: An appraisal of fundamentals and applications

Abstract

The application of mass spectrometry (MS) for structural elucidation in life sciences and bioanalytical approaches has become progressively significant. The recent advancements in MS have led to remarkable improvements in mass resolving power, mass accuracy, isotopic abundance accuracy, and accurate mass multiple-stage MS (n) capability, resulting in superior accuracy and precision in identifying and quantifying biomolecules. Furthermore, the advances in hardware and informatics tools for MS have paved the way for more efficient and accurate data acquisition and processing methods. In this review, we will elaborate on these improvements and summarize techniques such as ion mobility spectrometry (IMS), high-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), and data-independent acquisition (DIA) methods. The integration of MS with other analytical techniques such as chromatography, nuclear magnetic resonance (NMR), and X-ray crystallography has further improved the structural analysis of biomolecules. Overall, the ongoing progress in MS technology is anticipated to broaden its applications and influence in several fields.

URN:NBN:sciencein.jmc.2023.584