Charged Cyclodextrin-based self-assembly for Biosensing applications

Abstract

This review explores the application of charged cyclodextrins in biosensing systems, highlighting their unique advantages over neutral cyclodextrins. Charged cyclodextrins exhibit distinctive geometrical features, self-assembly capabilities, and molecular recognition properties, which make them highly effective in biosensing at the molecular level. The primary focus of this review is on the biosensing applications of charged cyclodextrin-modified sensors for detecting biomolecules, pharmaceuticals, and environmental pollutants, with a particular emphasis on systems utilizing fluorescent sensors. The key benefits of charged cyclodextrin-based systems include enhanced sensitivity, improved selectivity, and customizable structural attributes, allowing for targeted detection in complex environments. Additionally, this review discusses future perspectives, such as the integration of charged cyclodextrins with nanoscale systems, the potential for early disease detection, environmental pollution monitoring, and the development of wearable sensing devices. As one of the most promising advancements in biosensor technology, charged cyclodextrin-based sensors have opened new pathways for analytical applications in healthcare, environmental science, and beyond, offering innovative solutions to contemporary analytical challenges.