Synthesis and medicinal applications of quinoline hybrid heterocycles: a comprehensive review

Abstract

Quinoline is a privileged scaffold with immense studies carried out on its synthetic methods and wide range of biological properties. In order to intensify its properties and afford potent molecules, a variety of other heterocyclic units have been combined with quinoline in a single molecule. Since it was thought that these single, highly potent molecules can serve as replacements to combination therapies and overcome problems relating to drug-resistance, an array of various quinoline hybrids have been synthesized by different methods. In view of the growing use of quinoline moiety in drug design and development, this review focuses on the synthesis and biological applications of different quinoline hybrid scaffolds.

URN:NBN:sciencein.jmc.2022.338