Copper-catalyzed Click Chemistry for polyether-based dendronized multi-amphiphilic polymers and their applications

Abstract

Click chemistry and bio-orthogonal chemistry stands out as dynamic tools for chemists and biologists to snap together chemical entities as well as chemical and biological building blocks with just a click to construct a variety of intricate molecular structures with ease, rapidity, and selectivity. The ground-breaking work that contributed to developing click chemistry and bio-orthogonal chemistry has been acclaimed for its biocompatibility in biological environments, high reaction rates, and simplicity. Much interest has been shown in these reactions across several disciplines, but especially in the creation of DDS and pharmaceuticals. The utilization of "click" functionalization of enzymatically synthesized polyether-based polymeric scaffolds to generate dendronized polymers and their applications in biomedicine are summarized in this mini-review article. This compilation outlines the key techniques used to click functionalize linear polymers with dendrons to create amphiphilic denpols, with a focus on drug encapsulation and delivery. Considering the findings reported from 2013 to the present, prospects of polyether-based denpols have been highlighted.

URN:NBN:sciencein.jmc.2023.583.