Click Chemistry reactions: Fundamental mechanisms review of molecular conjugations

Abstract

The click chemistry reactions are the one leading conjugation protocols where two molecules can form the bonds in simple reaction conditions and at faster reaction rate. Understanding of the different methods and catalysts used for the click chemistry reactions provides the platforms for exploration of this reaction in construction of diversity of molecules. In this review, synthesis of triazolyl heterocycles via click chemistry with their in-depth molecular pathway mechanisms have been discussed. The regioselectivity of final products and role of catalysts involved have been present with a number of examples of heterocyclic molecules.