Imidazo[1,2] Coumarin analogues: Synthesis and antioxidant properties

coumarin analogues as antioxidant

Authors

  • Pooja Pooja University of Delhi https://orcid.org/0000-0001-8816-9318
  • Laishram Saya Devi
  • Aanshi Jain University of Delhi
  • Ashi Tokas University of Delhi
  • Anshu Sareen University of Delhi
  • Ankur Gupta University of Delhi

Keywords:

Coumarin, Antioxidant, Radical scavenging activity, DPPH, Imidazobenzothiazole, Spectrophotometric study, natural products, heterocyclic chemistry, organic synthesis

Abstract

Two coumarin derivatives, namely 3-benzo[d]imidazo[2,1-b]thiazol-2-yl)-chromen-2-one (IBT) and 3-(8-hydroxy-imidazo[1,2-a]pyridin-2-yl)-chromen-2-one (IMPY), were synthesized and their antioxidant properties were investigated using spectrophotometric methods. The percentage of radical scavenging activity (%RSA) for each compound was determined using the α, α-diphenyl-β-picrylhydrazyl (DPPH) assay method. A comparative analysis of the %RSA values obtained with those of ascorbic acid, a well-known antioxidant, revealed that both IBT and IMPY exhibited considerable antioxidant activity, indicating their potential as antioxidants. IBT demonstrated moderate antioxidant properties, with an %RSA value of 70.65% at a concentration of 10-3 M, which was slightly lower than that of ascorbic acid, but still significant.

URN:NBN:sciencein.jmc.2023.582

Author Biographies

  • Pooja Pooja, University of Delhi

    Department of Chemistry
    Sri Venkateswara College

  • Aanshi Jain, University of Delhi

    Department of Chemistry,
    Sri Venkateswara College

  • Ashi Tokas, University of Delhi

    Department of Chemistry,
    Sri Venkateswara College

  • Anshu Sareen, University of Delhi

    Department of Chemistry,
    Sri Venkateswara College

  • Ankur Gupta, University of Delhi

    Department of Chemistry,
    Sri Venkateswara College

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Published

2023-04-27

Issue

Section

Organic Chemistry

URN

How to Cite

(1)
Pooja, P.; Devi, L. S.; Jain, A.; Tokas, A.; Sareen, A.; Gupta, A. Imidazo[1,2] Coumarin Analogues: Synthesis and Antioxidant Properties. J. Mol. Chem. 2023, 3 (1), 582.

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