Synthesis, DNA binding, photocleavage, molecular docking studies of 2-oxo-3-quinoline-3-oximes

quinolines DNA cleavage

Authors

  • P.J. Bindu Indian Institute of Science, Bangalore
  • T.R. Ravikumar Naik Indian Institute of Science, Bangalore
  • S. Chandrasekar Indian Institute of Science, Bangalore
  • K.M. Mahadevan Kuvempu University

Keywords:

2-Oxo-quinoline-3-carbaldoxime esters, DNA Binding, DNA Photocleavage, Molecular docking , Anticancer activity, heterocyclic chemistry

Abstract

A series of 2-oxo-quinoline-3-carbaldoxime esters (OQCE) were designed and synthesized based on the 2-oxo-quinoline structure core as novel anticancer agents. The primary results shows that most of the compounds had moderate cytotoxicities against both tested human cancer cells. The oxygen analogue with alkoxy substituent significantly affected the cancer cells compare to other derivatives. Further, DNA binding, molecular docking and photonuclease studies activities of 2-oxo-quinoline-3-carbaldoxime esters (OQCE) were investigated. The experiment results showed that the prepared compounds have a good DNA binding and photocleavage activity. The molecular simulation results indicate that the presence of oxygen at second position of quinoline core structure improve the binding of designed molecules to DNA protein.

URN:NBN:sciencein.jmc.2022.444

Author Biographies

  • P.J. Bindu, Indian Institute of Science, Bangalore

    Department of Organic Chemistry

  • T.R. Ravikumar Naik, Indian Institute of Science, Bangalore

    Centre for Nano Science and Engineering (CeNSE)

  • S. Chandrasekar, Indian Institute of Science, Bangalore

    Department of Organic Chemistry

  • K.M. Mahadevan, Kuvempu University

    Department of Studies and Research in Chemistry

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Published

2022-12-05

Issue

Section

Medicinal Chemistry

URN

How to Cite

(1)
Bindu, P.; Naik, T. R. .; Chandrasekar, S.; Mahadevan, K. Synthesis, DNA Binding, Photocleavage, Molecular Docking Studies of 2-Oxo-3-Quinoline-3-Oximes. J. Mol. Chem. 2022, 2 (2), 444.

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