Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.
Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.
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Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.
Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.
In this paper, we report the design, synthesis, in-silico, and in-vitro evaluations of a series of coumarin-phenylthiazole conjugates to inhibit cholinesterase enzymes. The coumarin and phenylthiazole derivatives have been synthesized separately, and further combined through covalent amine bond linkage. The synthesized compounds showed more inhibition towards BuChE than AChE, where 4-(3-bromophenyl)-1,3-thiazol-2-amine (7i) exhibited the strongest inhibition against BuChE with an IC50 value of 3.54 μM. For the conjugates, 3-{2-[4-(3-nitrophenyl)thiazol-2-ylamino]acetyl}chromen-2-one (8j) exhibited strongest inhibition with an IC50 value of 46.47 μM. The better inhibition activities towards BuChE are also shown by 3-bromo and 2-fluoro derivatives. It was also observed that the substitution at 3-position, on phenylthiazole moiety produced better results against BuChE than 4-substituted counterparts.
Cite as: Mishra, D., Fatima, A., Singh, R., Munjal, N., Mehta, V., & Malairaman, U. (2019). Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors. Chemical Biology Letters, 6(2), 23-30.
Keywords:
nanophosphors, displays,
lanthanide, luminescence, composites,
LED
Abstract
A series of Eu3+ doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) was synthesized via sol-gel procedure at 950 oC.
The optical characteristics of the materials were studied by
Photoluminescence (PL) emission spectra. Upon 395 nm excitation and at
0.03 mole concentration of Eu3+ ion, these nanophosphors display optimum photoluminescence with most intense peak due to 5D0→7F2
(614-616) of dopant. Powder X-ray diffraction (PXRD) analysis proves
that all synthesized materials are of crystalline nature and
crystallinity improves on increasing temperature. Transmission electron
microscopy (TEM) exhibited the spherical shape of particles in 13-30 nm
size. Fourier Transformation infrared (FTIR) spectra showed peaks in
400-1000 cm-1 corresponding to gadolinium-oxygen and silicon-oxygen bond vibrations. In BaGd2Si3O10 material, Gd-O vibration is centered at 492 cm-1 and absorption band at 855 cm-1
is result of asymmetric vibrations of SiO in silicate tetrahedral unit.
Due to excellent photoluminescence and suitable CIE coordinates, these
materials could have brilliant applications in innovative displays.
Research
Highlights
Series of
trivalent europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+
and Ba2+)fluorescent
materials were synthesized successfully with sol-gel
procedure.
The prepared samples were characterized
using Photoluminescence analysis, X-ray diffraction study, Transmission
Electron Microscopic analysis and Fourier Transform Infrared spectroscopy.
The CIE color coordinates values of
phosphor confirmed the red color of complex approving the PL results.
X-ray diffraction pattern of these
materials determined the particle size using Debye Scherrer’s equation.
Excellent photoluminescence response and
nano size of these materials made them suitable for various innovative display applications.
Cite as: Sheoran, S., Singh, S., Mann, A., Samantilleke, A., Mani, B., & Singh, D. (2019). Novel synthesis and Optical investigation of trivalent Europium doped MGd2Si3O10 (M = Mg2+, Ca2+, Sr2+ and Ba2+) nanophosphors for full-color displays. Journal of Materials NanoScience, 6(2), 73-81.
Nanoparticle ferrite with chemical formula CoFe2O4 was prepared from the Co (II) and Fe (III) 3-acetyl-4-hydroxy-coumarin metal complexes by solution based one-pot microwave assisted technique. Single phase structure of CoFe2O4 ferrites nanoparticles was confirmed using FTIR, XRD, SEM, and EDX analysis. Transmission Electron Microscope (TEM) showed that the particle size of the samples in the range of (15 nm). The hysteresis studies showed ferromagnetic behaviour at room temperature. The antifungal activity of CoFe2O4 nanoparticle was investigated against A.flavus and A. niger by employing disc diffusion method. According to the results obtained, CoFe2O4 is a potential material for antifungal diseases. The CoFe2O4 nanoparticles could be readily separated from water solution after the disinfection process by applying an external magnetic field.
How to Cite Naik, T. R. R., Joshi, N., Shivashankar, S., & Bindu, P. (2019). Low-temperature microwave-assisted synthesis and antifungal activity of CoFe2O4 nanoparticles. Journal of Materials NanoScience, 6(2), 67-72.
The development and evaluation of new drug delivery systems (particularly with nanoscale materials) has been potentiating the advances in drug development. This special issue is meant to cover recent advances in development and application of nano delivery systems, peptide based delivery systems, self assembly of peptides structures and similar natural systems, Gene delivery, lipids, liposomes, miscelle, nanoparticular and carbon nanomaterials in drug delivery, mechanistic understanding of delivery systems, and other development of nanomaterials for drug delivery in medicinal chemistry.
Issue Editors:
Prof. Keykavous Parang
Associate Dean of Research, Graduate Studies, and Global Affairs
Professor of Medicinal Chemistry and Pharmacology
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Rd.
Irvine, CA 92618-1908. USA
Dindyal Mandal
Senior Research Associate
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Rd.
Irvine, CA 92618-1908. USA
Dr. B.S. Chhikara
Department of Chemistry, University of Delhi, Aditi Mahavidyalaya, Delhi 39. India
Submission
Article (Research articles and Review Articles) should be submitted online on the journal site http://www.pubs.thesciencein.org/journal/index.php/jmns as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.
Authors may also forward their final manuscript to editors via email ( bschhikara (at) gmail [dot] com )
Submission
Deadline
Submission ongoing, issue completion by March 2020
There is no publication charges for publishing in special issue.
Synthesis, Characterization, Biocompatibility of Curcumin loaded Silica NP’s & their Therapeutic Applications: A Review Parul Pant, Chetna Gupta, Sagar Kumar, Apoorva Grewal, Shivani Garg, Aishwarya Rai (under process)
Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC Pooja Mittal, Sujata Singh, Archana Singh, Indrakant Kumar Singh (under process)
Running title: Rationale of designing of nanoparticular delivery systems and impact of chemistry used with doxorubicin for anti-cancer therapy
Bhupender S. Chhikara
University of Delhi
Brijesh Rathi
University of Delhi
Keykavous Parang
Chapman University
Keywords:
Adriamycin, Cancer Drug,
CPP, Drug Delivery System, Lipophilic Dox,
TAT peptide
Abstract
Doxorubicin (Dox), an antineoplastic drug, has been extensively used for the treatment of different cancers. Dox is hydrophilic and therefore distributes to normal organs at a faster rate. Due to its required high doses, it poses severe toxicity, such as cardiotoxicity and nephrotoxicity. Diverse approaches, including nanoparticulate delivery systems, have been designed and evaluated to improve its delivery to the target site and reduce toxicity to normal organs; however, this has met little success. Here in this review, we have discussed various systems (metal nanoparticles, carbon nanotubes, fullerenes, liposomes, dendrimers, cyclic peptides, and other covalent/non-covalent systems) that have been used for Dox. We have critically evaluated their designing and outcome (in vitro and in vivo) with potential applications in the clinical setting.
Cite as: Chhikara, B., Rathi, B., & Parang, K. (2019). Critical evaluation of pharmaceutical rational design of Nano-Delivery systems for Doxorubicin in Cancer therapy. Journal of Materials NanoScience, 6(2), 47-66.
Despite the noteworthy advances in the use of chemotherapy for malaria, it continues to constantly affect large number of individuals. New molecules capable of blocking life-cycle of the parasite, preferably through targeting novel pathways and various modes of action, are increasingly becoming area of interest. Phenotypic screening of large chemical libraries is certainly one of the important criteria for the discovery of new and effective drugs. In recent years, diverse research groups including pharmaceutical industries have performed this large-scale phenotypic screening to identify the potential drug molecules. Most of the antimalarial drugs target blood-stage malarial infection and remain either less potent or ineffective against other life stages i.e. liver-stage, and the gametocyte stages of the parasite. Although, liver stage is considered as a crucial drug target, limited clinical options have significantly hampered the discovery of effective treatments. This short review presents the collection of selective molecules targeting specifically liver stage malaria parasites.
Cite as: Sharma, N., FNU, P., Kempaiah, P., & Rathi, B. (2019). Chemical libraries targeting Liver Stage Malarial infection. Chemical Biology Letters, 6(1), 14-22.
Nanoenergy is fast growing field with promises to bring new energy systems to meet the demand and define new technologies of future. The special issue of Nanoenergy cover the recent advances in the field and solicit articles from researchers related to following subfields:
Photovoltaic nanomaterials, Perovskite cells, Nanophotonics, Nanosolar cells, New nanomaterials for solar energy harvesting, Nanothermal energy systems, Nanosystems for harvesting mechanical and other forms of energy, Nanogenerator, higher efficiency nanomaterials for existing energy systems (production, transportation and storage), Nanostorage systems for energy, Nanobattery (design and development), Environmental issues concerned with nano energy systems, MEMS, Semiconductor design for energy systems, Carbon nanomaterials based energy generation and storage systems, new nanoenergy nanomaterials properties evaluation and all other research advances related to nanoenergy subtopics/
Editors of NanoEnergy special issue
Dr. Trilok Singh School of Energy Science & Engineering Sir J.C. Bose Laboratory Complex Indian Institute of Technology Kharagpur Kharagpur – 721302, West Bengal, India
Dr. Bidhan Pramanick Electrical Engineering Department Indian Institute of Technology Goa, India
Dr. B.S. Chhikara University of Delhi, Delhi, India.
Manuscript Submission
Authors need to submit their manuscript in the NanoEnergy section of the journal. The manuscript should be formatted as per journal format provided in author guidelines section.
Article types: Research Article, Review Article, Short Communications, Experts Opinion article (contact editors before submission of Experts opinions articles).
Last date: The submissions are open now, author can submit their manuscript now, the last date for submissions to be considered in this issue is October 31.
Just to mention that There is no APC or authors fees for publication in the special issue.
