Synthesis of novel ?-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

Authors

  • Ashish Bhatt Mewar University
  • Krishna Srivastava Shri Ramswaroop Memorial University
  • Ravi Kant Shri Ramswaroop Memorial University
  • Deepa Lakhmani Shri Ramswaroop Memorial University

Abstract

Selected novel ?-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for ?-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain

Author Biographies

  • Krishna Srivastava, Shri Ramswaroop Memorial University

    Chemistry, Dean  Faculty of Chemical Sciences, 

  • Ravi Kant, Shri Ramswaroop Memorial University

    Chemistry, Professor

  • Deepa Lakhmani, Shri Ramswaroop Memorial University

    Chemistry, Research Scholar

antibacterial heterocycles

Published

2019-11-12

Issue

Section

Articles

How to Cite

Synthesis of novel ?-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. (2019). Chemical Biology Letters, 6(2), 46-54. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/35