Synthesis, antimicrobial and antimalarial study of novel 1,3,4-thiadiazole derivatives incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties

Abstract

A new class of 1,3,4-thiadiazole derivatives 8a-i incorporating imidazo [1,2-b] pyridazine and thiazolidinone moieties were synthesized by the reaction of arylidene derivatives  of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety (Schiff base) 7a-i with thioglycolic acid. Schiff base 7a-i were synthesized by the reaction of 1,3,4-thiadiazoles 2-amine having imidazo [1,2-b] pyridazine moiety 6 with substituted benzaldehyde. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus Pyogenes and Staphylococcus aureus) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) as well as for antifungal and antimalarial activity against plasmodium falciparum strain. Compound 8a and 8b exhibited good antimicrobial and antimalarial activity.