Copper-catalyzed ambient synthesis of functionalized 1,4-Dihydropyridines
Keywords:1,4-Dihydropyridines, dimedone, catalysis, organic synthesis, copper sulphate, heterocycles synthesis, heterocyclic compounds, ambient condition synthesis
1,4-Dihydropyridine moiety has received much attention due to the wide spectrum of biological activities associated with it. An array of functionalized 1,4-Dihydropyridines has been synthesized in ambient conditions utilizing the catalytic properties of cupric sulfate pentahydrate. The entire focus of the present work has been to develop a ‘benign by design’ protocol with short reaction times and a simple reaction procedure. A wide substrate scope, good product yield, use of an eco-friendly solvent, a re-cyclable catalyst, as well as a reaction at ambient temperature are the advantages of this method. The catalyst cupric sulphate pentahydrate is indispensable for carrying out the reaction at room temperature.
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