A facile synthesis of Guanyl Hydrazones: Potent Advance Glycation End products’ (AGE) inhibitors

Abstract

A scaffold of potential Advance Glycation End products (AGE) inhibitor, guanyl hydrazones substituted with different functional groups, has been synthesized by facilitating a condensation reaction between differently substituted chalcones and guanyl hydrazone hydrochloride under microwaves, using anhydrous K₂CO₃ as green solid support. The free hydrazones were obtained in high yields through an aqueous post-reaction work-up eliminating the use of organic solvent as well as an external base. Hence an efficient and environmentally benign protocol was developed for the synthesis of the target compounds.

URN:NBN:sciencein.jist.2023.v11.512