A facile synthesis of Guanyl Hydrazones: Potent Advance Glycation End products’ (AGE) inhibitors
Keywords:Chalcone, aminoguanidine hydrochloride, Guanylhydrazone, microwave irradiation, AGE, microwave synthesis
A scaffold of potential Advance Glycation End products (AGE) inhibitor, guanyl hydrazones substituted with different functional groups, has been synthesized by facilitating a condensation reaction between differently substituted chalcones and guanyl hydrazone hydrochloride under microwaves, using anhydrous K2CO3 as green solid support. The free hydrazones were obtained in high yields through an aqueous post-reaction work-up eliminating the use of organic solvent as well as an external base. Hence an efficient and environmentally benign protocol was developed for the synthesis of the target compounds.
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