Mathematical modeling of Ryanodine receptor for Alzheimer's disease

Alzeihmer's disease modeling

Authors

  • Sonupriya Roy Ganpat University
  • Vijay Dave Government Engineering College, Gandhinagar

Keywords:

Alzheimer's disease, neurodegenerative disease, calcium, Ryanodine receptor, Open Probability, Molecular Modeling

Abstract

Increased intracellular calcium is important for action potential, Long Term Potentiation (LTP) and Long-Term Depression (LTD), neuron transmitter release and many more. Calcium influx from channel, present on plasma membrane, is amplified by calcium release from Endoplasmic reticulum (ER) via IP3 and Ryanodine Receptor (Ryr). As there is increase in Ryr open probability and its expression in Alzheimer 's Disease (AD), so we targeted Ryr for further study. We studied the effect of AD on Ryr open probability, by varying the required parameter and compared it with open probability of Ryr in normal condition. We found a significant difference between open probability and calcium release response from Ryr. So, Ryr can be targeted for further therapeutic study, to control Ryr open probability using computational modelling.

URN:NBN:sciencein.jist.2024.v12.716

Author Biographies

Sonupriya Roy, Ganpat University

Department of Biomedical Engineeirng, Institute of Technology

Vijay Dave, Government Engineering College, Gandhinagar

Department of Biomedical Engineeirng

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Published

2023-09-07

How to Cite

Roy, S., & Dave, V. (2023). Mathematical modeling of Ryanodine receptor for Alzheimer’s disease. Journal of Integrated Science and Technology, 12(1), 716. Retrieved from https://pubs.thesciencein.org/journal/index.php/jist/article/view/a716

Issue

Vol. 12 No. 1 (2024)

Section

Engineering

URN

https://scholar.google.com/scholar?q=urn:nbn:sciencein.jist.2024.v12.716

License

Copyright (c) 2023 Sonupriya Roy, Vijay Dave

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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