Mathematical modeling of Ryanodine receptor for Alzheimer's disease

Abstract

Increased intracellular calcium is important for action potential, Long Term Potentiation (LTP) and Long-Term Depression (LTD), neuron transmitter release and many more. Calcium influx from channel, present on plasma membrane, is amplified by calcium release from Endoplasmic reticulum (ER) via IP3 and Ryanodine Receptor (Ryr). As there is increase in Ryr open probability and its expression in Alzheimer 's Disease (AD), so we targeted Ryr for further study. We studied the effect of AD on Ryr open probability, by varying the required parameter and compared it with open probability of Ryr in normal condition. We found a significant difference between open probability and calcium release response from Ryr. So, Ryr can be targeted for further therapeutic study, to control Ryr open probability using computational modelling.

URN:NBN:sciencein.jist.2024.v12.716