Oxidative stress and antioxidants in reproductive health and disorders – Special Issue

Infertility affects 15% of couples worldwide and is a major health issue. One of the primary reasons for infertility is oxidative stress (OS), which is defined as an imbalance in the amounts of reactive oxygen species (ROS) and antioxidants. In case of male reproduction, physiological functions of sperm, especially capacitation, hyperactivation, and acrosomal reaction, require a modest level of ROS. However, excessive ROS generation can inactivate vital enzymes and oxidize proteins in spermatozoa, lipid peroxidation or DNA damage, leading to infertility. Major sources of ROS include immature spermatozoa, inflammatory agents, genetic mutations, and altered sex hormone levels. In case of female reproduction, existing literature suggest that ROS affect oocyte development, maturation, follicular atresia, corpus luteum function, and luteolysis. Mechanisms of OS-mediated female reproductive tract disorders resemble those of male infertility to a substantial extent. Since OS is caused by deficiency in antioxidants, adopting a healthier lifestyle and taking antioxidant supplements are used as conventional treatment for OS-mediated infertility.
This special issues aims to highlight the physiological ROS generation, genetic and epigenetic influences on OS and infertility; and also to present an updated in-depth insight on the mechanism involved in OS-induced infertility, including lipid peroxidation, DNA damage, hormone profile imbalance, inflammation, etc. Finally, the special issue intends to discuss the beneficial impacts and limitations of using antioxidants in treating male and female infertility.

Potential topics include but are not limited to the following:
● Oxidative stress in male and female infertility
● Systemic diseases and reproduction: oxidative stress as the key player
● Endocrine disruption, oxidative stress and reproduction
● Infection, inflammation and oxidative stress in reproductive pathophysiology
● Antioxidants in the mitigation of oxidative stress induced reproductive disorders


Dr Pallav Sengupta and Dr. Sulagna Dutta

 Important Dates

Full Article Submission date- April 15, 2023
Issue completion date – June 1, 2023


Interested scholars should submit their article (prepared according to author guidelines in the journal article template) on the journal site https://pubs.thesciencein.org/journal/index.php/jist 

Authors should submit their article manuscript directly to guest editors for preliminary editorial processing.

Participating Journal

Journal of Integrated Science and Technology


Immunoendocrine regulation of energy homeostasis and male reproduction

Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive hormones and immune regulators, a better understanding of these chemical regulations will potentiate further research in this direction.

This issue aims to summarize the current knowledge on the hormonal and immunological regulations of male reproductive functions in physiological and pathophysiological conditions of male reproduction.

Potential topics include but are not limited to the following:

  • Energy homeostasis  and male reproduction
  • Immunoendocrine regulation of male reproductive functions
  • Adipokines and energy metabolism in male fertility
  • Obesity and male infertility: energy imbalance to inflammation
  • Endocrine regulation of epigenetics of reproductive tract inflammation
  • Altered energy metabolism and immune regulation in aged men
Submission Deadline30th June 2021 15th July 2021
Publication Date1st Sept 2021

Issue published, Read the articles at https://pubs.thesciencein.org/journal/index.php/cbl/issue/view/20

Guest Editors:

Pallav Sengupta, PhD
Department of Physiology
Faculty of Medicine & Biomedical Sciences
MAHSA University
[pallav@mahsa.edu.my; pallav_cu@yahoo.com]
Sulagna Dutta, PhD
Department of Physiology
Faculty of Dentistry
MAHSA University
[duttasulagna@mahsa.edu.my; sulagna_dutta11@yahoo.com]


Article (Research articles and Review Articles) should be submitted online on the journal site http://www.pubs.thesciencein.org/journal/index.php/cbl as per author guidelines. Authors need to indicate submission to special issue in cover letter to editor.

Issue published, Read the articles at https://pubs.thesciencein.org/journal/index.php/cbl/issue/view/20

There is no publication charges for publishing in special issue or in Chemical Biology Letters.