Fertility treatment-induced oxidative stress and reproductive disorders

Abstract

Rising global infertility rates have amplified the dependence on assisted reproductive technologies (ARTs) for conception. This necessitates a thorough examination of fertility drug effects on reproductive health. This review explores the impact of fertility drugs, such as antioxidants, antibiotics, and anti-inflammatory agents, on oxidative stress (OS), reproductive irregularities, and treatment outcomes. While antioxidants can potentially improve reproductive outcomes by modulating OS, excessive consumption can lead to the ‘antioxidant paradox’ — a delicate balance between external antioxidant intake, OS reduction, and its effects on fertility. Moreover, some antibiotics and anti-inflammatory drugs can intensify OS, possibly exacerbating reproductive issues. The article emphasizes the complex relationship between fertility drugs and ovarian stimulation, highlighting the need for personalized treatments and careful weighing of the advantages and drawbacks of fertility interventions. This review emphasizes the intricate relationship among fertility drugs, ovarian stimulation, and semen quality, advocating for personalized treatment plans and a thorough assessment of the benefits and drawbacks of fertility interventions. The comprehensive insights obtained from this extensive review aims to aid clinical protocols and support informed decisions in reproductive medicine.

URN:NBN:sciencein.jist.2024.v12.756