Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

antioxidant female reproduction

Authors

  • Sulagna Dutta Manipal Academy of Higher Education (MAHE), Dubai
  • Pallav Sengupta Gulf Medical University, Ajman
  • Emmanuel Izuka University of Nigeria
  • Ifeanyi Menuba University of Nigeria
  • Uchenna Nwagha University of Nigeria

DOI:

https://doi.org/10.62110/sciencein.jist.2024.v12.754

Keywords:

female infertility, oocyte quality, oxidative stress, reactive oxygen species

Abstract

Oxidative stress (OS), caused by an imbalance between oxidants and antioxidants in the body, is pivotal in influencing female reproductive health. This review explores the complex interactions of oxidizing agents and antioxidants on female reproductive functions, underscoring their impact on fertility, pregnancy, and reproductive outcomes. Primarily resulting from excessive reactive oxygen species (ROS), OS can detrimentally affect oocyte maturation, embryonic development, and endometrial receptivity. Although ROS naturally arise during cell metabolism, their overproduction or insufficient neutralization can damage cellular macromolecules, including lipids, proteins, and DNA. Such disruptions can lead to ovarian issues, recurrent pregnancy losses, and conditions like endometriosis and polycystic ovary syndrome (PCOS). Conversely, antioxidants, both enzymatic and non-enzymatic, combat excess ROS, promoting cellular balance and reproductive success. Emerging treatments underscore the benefits of boosting antioxidant levels to address OS-related disorders. However, caution is essential due to potential risks of excessive antioxidant intake. The review underscores the critical association between OS and female reproductive functions, suggesting customized therapeutic strategies for improved reproductive outcomes.

URN:NBN:sciencein.jist.2024.v12.754

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Author Biographies

  • Sulagna Dutta, Manipal Academy of Higher Education (MAHE), Dubai

    School of Life Sciences

  • Pallav Sengupta, Gulf Medical University, Ajman

    College of Medicine

  • Emmanuel Izuka, University of Nigeria

    College of Medicine

  • Ifeanyi Menuba, University of Nigeria

    College of Medicine

  • Uchenna Nwagha, University of Nigeria

    College of Medicine

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Published

2023-11-06

Issue

Section

Biomedical and Pharmaceutical Sciences

URN

How to Cite

Dutta, S., Sengupta, P., Izuka, E., Menuba, I., & Nwagha, U. (2023). Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants . Journal of Integrated Science and Technology, 12(3), 754. https://doi.org/10.62110/sciencein.jist.2024.v12.754

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