Reproductive Inflammatory Mediators and Male Infertility

Abstract

Disruption of semen quality in cases of testicular and accessory gland infections, owe to altered spermatogenesis, sperm maturation and/or transport. The impact depends on the intensity, duration of progression, mediators of the inflammatory process and individual susceptibility to the infection. Interactions among the mediators with immunological cells and other regulators affect sperm function and have been reported to be associated with male infertility. However, the issue is still under debate and paves several dimensions of research in this realm. The summarized discussion of articles about the current knowledge on male reproductive tract inflammation and causative agents with its consequences on male reproductive functions have been included.