Category: Readings
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Association of C-peptide with novel hormones in children with type 1 diabetes: A rising potentials for more reliable biomarkers.
Association of C-peptide with novel hormones in children with type 1 diabetes: A rising potentials for more reliable biomarkers. Type 1 diabetes is a heterogeneous disorder caused by reduced β-cell mass as a result of T-cell mediated autoimmune destruction. C-peptide is a linker chain cleaved from proinsulin to produce the mature, functional insulin hormone. Irisin…
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Synthesis of novel imidazolo-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids as in vitro EGFR inhibitors
Synthesis of novel imidazolo-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids as in vitro EGFR inhibitors The synthesis of new hybrid [1,2,4] triazolo [3,4-b][1,3,4]thiadiazine derivatives of imidazole (5a – 5m) and their structure determination using 1HNMR, 13CNMR and mass spectral analysis were described. The in vitro cytotoxic activity of the compounds (5a – 5m) against three human cancer cell lines like…
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Ten essential points incorporation in final manuscripts
The proper formatting and inclusion of essential details in the manuscript are necessary to make the work / article suitable for international readers. Any article submitted to The ScienceIn journals should be updated for the following points (It is must for accepted articles): 1. Title, Author Name, Affiliation, Abstract, Keywords Title, Author Name, Affiliation, Abstract…
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Anti-prostate cancer and anti-EGFR activities of new Nilutamide-isoxazole hybrids
Anti-prostate cancer and anti-EGFR activities of new Nilutamide-isoxazole hybrids Herein, synthesis of new Nilutamide-isoxazoles (5a-5n) via Cu(I)-promoted one-pot reaction between 1-(but-3-yn-1-yl)-5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione (3) and several aldehydes (4a-4n) in benign aq. tbutanol as key approach has been reported. The in vitro growth inhibition activity of all these compounds revealed that the majority of compounds were more active…
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Bioorthogonal chemistry in the reproductive medicine
Bioorthogonal chemistry in the reproductive medicine The expanding field of bioorthogonal chemistry has demonstrated significant potential in advancing reproductive medicine. This comprehensive review elucidates the multifaceted applications of bioorthogonal chemistry across various aspects of reproductive medicine, including gamete biology, energetics and metabolic regulations of gametes, targeted drug delivery, detection and therapeutic of endometriosis and polycystic…
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Novel fluorinated piperazine based-amino acid derivatives as antiplasmodial agents: Synthesis, bioactivity and computational studies
Novel fluorinated piperazine based-amino acid derivatives as antiplasmodial agents: Synthesis, bioactivity and computational studies A library of twenty novel analogues of fluorinated, N-(3-hydroxy-1-phenyl-4-(4-phenylpiperazin-1-yl)alkyl)amides containing different amino acids were synthesized and tested for the activity against Plasmodium falciparum (Pf3D7) culture. All the tested compounds showed TC50 values >100 µM on HepG2 cells. Hit analogues 12c and…
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Dietary Polyphenolics: Mechanistic role in control management of Diabetes and Metabolic Syndrome
Dietary Polyphenolics: Mechanistic role in control management of Diabetes and Metabolic Syndrome The search for an antidiabetic drug is going on three fronts: technological (for instance, development of an artificial pancreas), biological (such as pancreas and islet cell transplants), and pharmacological. Our review focusses on the role of polyphenolics in pharmacological research for T2DM. Being…
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2023 Young Laureate (Citations) Award
The ScienceIn has instituted the authors awards for encouraging the quality contents publication by the authors. In the category, Young Laureate (Citations) Award is awarded for the relevant article published in the ScienceIN journals on achieving the good citations in a year. The 2023 Young Laureate (Citations) Award has been announced for the article Recent…
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Recent trends in synthetic Top-down approach for Mesoporous Carbon: A seminal review
This review is focused on the different synthetic methods of mesoporous carbon for exotic applications. In the 21st century, doped carbon nanostructures and composites have cutting-edge applications in materials sciences due to their superior physicochemical properties. Porous carbon has enticed material scientists because of its excellent properties like ordered porous structure, tunable pore size, and…
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Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies
Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies Chemical warfare agents, especially organophosphorus (OP) compounds, are known for their extreme toxicity causing inhibition of acetylcholinesterase (AChE) enzyme activity due to covalent phosphorylation. This leads to functional impairment of muscarinic nicotinic acetylcholine receptors, resulting in…