Category: Medicinal Chemistry
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Chemerin and male reproduction: ‘a tangled rope’ connecting metabolism and inflammation
Adipokines are peptides produced mainly by the fat tissue adipocytes and their levels are sensitive to alterations in metabolic state. While there is little known about the impact of adipokines on male reproductive control, both animal-based experimental data and clinical research suggest that they can influence numerous male fertility indices. Chemerin is a newly found…
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An economic and efficient synthesis of acid-labile glycerol based β-thiopropionate esters for potential application in drug delivery
Acid labile linkers have been used widely for various biomedical applications with preferential applications in drug delivery. In this report, we have synthesized, glycerol based b-thiopropionate esters having an acid-labile β-thiopropionate linker with Michael addition reaction between hydrophobic thiol and hydrophilic tri-glycerol diacrylate. The solvent free reaction and purification by simply solvent extraction instead of…
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Assessing the antimycobacterial activity of the bioactive fractions of the Indian medicinal plant – Justicia adhatoda L.
Justicia adhatoda L. is an Indian medicinal plant traditionally used to treat respiratory ailments in Ayurvedic and Unani medicines. It is widespread in the Indian subcontinent. The plant leaves are known to have broad range of pharmacological activities including analgesic, anti-inflammatory, antispasmodic and antibacterial properties. Some studies have highlighted the antimicrobial effects of its major…
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Infections and Immunity
A special thematic issue meant to cover the various aspects of emerging infectious diseases, problems, and solutions to deal with possible infections of future.
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Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor
One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol…
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Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air
Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and…
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Biosensors for Detecting Imbalances of Life Systems: Role of Materials and Methods in Improved Outcome
Special issue on Biosensors: materials and methods Lead 20 program
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Immunoendocrine regulation of energy homeostasis and male reproduction
Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive…
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Clinical and Pre-Clinical advances in Medicinal Chemistry – Special Issue Chemical Biology Letters
The medicinal Chemistry, the science concerned with development of new drug molecules, has produced many new drug entities recently which has reached in the clinical trial stages of evaluation. This special issue is meant to cover the research advances in development of new drug molecules and science behind it (including molecular modeling and pharmaceutical science)…
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Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?
Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating…