Category: Medicinal Chemistry
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Immunoendocrine regulation of energy homeostasis and male reproduction
Male reproduction and its intricate neuroimmunoendocrine regulations open a wide scope of scientific interventions. Male infertility, being responsible for about half of the overall global infertility cases, represents a complex pathophysiological mechanism. Crosstalk among the endogenous immune and endocrine mediators may affect male gonadal functions. Since male reproduction is fine-tuned by orchestrated regulation of reproductive…
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Clinical and Pre-Clinical advances in Medicinal Chemistry – Special Issue Chemical Biology Letters
The medicinal Chemistry, the science concerned with development of new drug molecules, has produced many new drug entities recently which has reached in the clinical trial stages of evaluation. This special issue is meant to cover the research advances in development of new drug molecules and science behind it (including molecular modeling and pharmaceutical science)…
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Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?
Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating…
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Chemical libraries targeting Liver Stage Malarial infection
urn:nbn:sciencein.cbl.2019v6.96 Chemical Scaffolds Targeting liver-stage malaria parasite lifecycle Published in: Chemical Biology Letters Neha Sharma Poonam FNU Prakasha Kempaiah Brijesh Rathi University of Delhi Keywords: Malaria, Liver stage, Primaquine, Atovaquone, Clinical trials Abstract Despite the noteworthy advances in the use of chemotherapy for malaria, it continues to constantly affect large number of individuals. New molecules…