Proniosome-based smart delivery systems for Psoriasis-targeted bioactive therapy

Abstract

The growth in the field of nanotechnology has brought forth the growth of several breakthroughs that have prompted formulation of new solutions. Nanocarriers occur as minute encapsulating agents of the drug molecules thus stabilizing and improving the therapeutic effects of the encapsulated drugs. The self-assembly characteristic of proniosomes reduces the challenges that are normally encountered in liposomal and niosomal drug delivery systems. Due to their ability to self-assemble, proniosomes are the focus of constant investigating in the field of drug delivery systems. However, there is still great potential for future research concerning the development of new carrier materials for proniosomal formulation. Versatile proniosome-derived niosomes prove to be a reliable and relatively inexpensive system for drug delivery that possesses a number of significant advantages over conventional vesicular and traditional pharmaceutical formulations. Bioactive agents and recent advancements along with ethical considerations in the formation of proniosomes for psoriasis is further discussed in this review article. Novel hypotheses estimate repeated improvements in oral biopharmacokinetics, preferential drug targeting to the site of action, postponing the systemic biotransformation of the drug, which would lead to minimizing toxicity.