Isolation, synthesis and medicinal applications of Heparin

Authors

  • Saikrushna Jena Delhi Technological University
  • Ram Singh Delhi Technological University

Keywords:

Heparin, glycosaminoglycan, biopolymer, anticoagulant, drug delivery

Abstract

Heparin is a highly sulphated and most negatively charged natural biopolymer belonging to the glycosaminoglycan (GAG) family. This is about a 100-year-old anticoagulant drug. This is equally important for non-anticoagulant diseases also and is the reason for the recent burgeoning of interest in the molecule. Heparin has been isolated from both animal and non-animal sources; however, porcine mucosa remains the FDA-approved source for heparin. For the synthesis, chemical, chemoenzymatic, and biotechnological approaches have been studied. In recent times, the focus is more on synthesizing LMWH, ULMWH, and bioengineered heparins. This article is a compilation about the isolation, synthesis, and medicinal applications of heparin.

Author Biography

Ram Singh, Delhi Technological University

Department of Applied Chemistry, Delhi Technological University, Delhi-110 042, India

heparin

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Published

2021-06-01

How to Cite

Jena, S., & Singh, R. (2021). Isolation, synthesis and medicinal applications of Heparin. Chemical Biology Letters, 8(2), 59–66. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/248

Issue

Section

Review Articles