Category: Readings
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Design, synthesis and biological evaluation of novel sulfamoyl benzamides as allosteric activators of human glucokinase
Design, synthesis and biological evaluation of novel sulfamoyl benzamides as allosteric activators of human glucokinase Glucokinase (GK) activators, which target the GK enzyme, are an emerging class of therapeutics with promising effects against diabetes. The objective of this work was to create a new group of sulfamoyl benzamide derivatives with the ability to activate GK…
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Molecular pathways with role to play in oral cancer: A mini-review
Molecular pathways with role to play in oral cancer: A mini-review Oral cancer is the sixth most prevalent type of cancer worldwide and third in India out of the different cancer types identified. Mouth and oral cancers collectively refer to cancers of the buccal cavity, lips, oropharynx, hypopharynx, and larynx. Genetic anomalies, the upregulation of…
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Synthesis of Indole-Oxadiazole coupled isoxazole hybrids as potent EGFR targeting anticancer agents
Synthesis of Indole-Oxadiazole coupled isoxazole hybrids as potent EGFR targeting anticancer agents The synthesis of new indole-oxadiazole coupled isoxazole hybrids (6a–o) synthesized by the Cu(I)-catalyzed reaction of in situ generated nitrile oxides with 3-(3,5-dichloro-4-methoxyphenyl)-5-(1-(prop-2-yn-1-yl)-1H-indol-3-yl)-1,2,4-oxadiazole in good yields have been reported here. The chemical structures of all newly synthesized hybrids were confirmed by 1H-NMR, 13C-NMR, and…
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Impact of resistin gene polymorphism on insulin resistance and Type 2 diabetes in Iraqi Babylon province patients
Impact of resistin gene polymorphism on insulin resistance and Type 2 diabetes in Iraqi Babylon province patients Resistin is cysteine-rich polypeptide produced by adipocytes and macrophages. This study aims to assess the role of resistin and its gene polymorphisms (rs-34861192 G>A, NG-023447 C>G) as potential link between obesity and insulin resistance in the development of…
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Synthesis of 1,4-disubstituted-1,2,3-Triazole derivatives for investigation of inhibition and molecular docking studies against Xanthine Oxidase
Synthesis of 1,4-disubstituted-1,2,3-Triazole derivatives for investigation of inhibition and molecular docking studies against Xanthine Oxidase This study evaluates the inhibition effect of new 1,4-disubstituted-1,2,3-triazoles against Xanthine Oxidase supplemented by molecular modelling. Nine compounds of 1,4-disubstituted-1,2,3-triazoles by Sharpless’s approach have been synthesized in this report. The structures of the synthesized compounds were characterized using FT-IR, 1H…
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Synthesis of novel phthalimide-based piperazine conjugated analogs as anti-malarial agents
Synthesis of novel phthalimide-based piperazine conjugated analogs as anti-malarial agents In the present report, we synthesized twelve novel phthalimide analogs and evaluated for antiplasmodial efficacy on Plasmodium falciparum culture. Two molecules exhibited significant inhibition percentages at 1 µM concentration without any apparent cytotoxicity on HepG2 cells. Inhibitory concentration (IC50) for both the hit compounds 6d…
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Small-molecules against Oxidative stress mediated Neurodegenerative diseases
Small-molecules against Oxidative stress mediated Neurodegenerative diseases Neurodegenerative diseases, marked by the gradual deterioration of neuronal structure and function, impose a significant burden on global healthcare systems. Oxidative stress, resulting from an imbalance between reactive oxidant production and cellular antioxidant defense, is believed to play a significant role in the development of various neurodegenerative disorders,…
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Molecular links between metabolome and epigenome: AMPK-TET2 signalling pathway and their natural activators
Molecular links between metabolome and epigenome: AMPK-TET2 signalling pathway and their natural activators Emerging evidence suggests that sustained diabetes-associated factors such as inflammation, hyperinsulinemia, and hyperglycemia are major contributors to aberrant cell proliferation and subsequent neoplastic transformation. Epidemiological studies have also highlighted that diabetes promoting a sedentary lifestyle, with or without the direct involvement of…
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Synthetic polymer nano-film coating efficacy evaluation in prevention of chemicals induced corrosion of monuments
One of the most notable adverse effects of acidifying air quality is damage to materials exposed to the atmosphere. Systematic fields and laboratory experiments have been done to understand the mechanisms underlying the impacts of pollutants on the measurement of damage and estimate the cost of damage. In this study, authors have synthesized nano polymer…
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Chemical composition and additive inhibitory activity of combination of Mentha piperita, Cinnamonum vernum & Jasminum officinale essential oils as an alternative therapy against Dermatophytosis
Chemical composition and additive inhibitory activity of combination of Mentha piperita, Cinnamonum vernum & Jasminum officinale essential oils as an alternative therapy against Dermatophytosis The antifungal potential of Peppermint, Cinnamon & Jasmine essential oils alone and in combination, against common causes of superficial fungal infections in humans was investigated via in-vitro investigations, in order to…