Category: CBL Articles
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Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?
Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating…
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1,3,4 Oxadiazole: An emerging scaffold to target different growth factors and kinases
Five member heterocyclic 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. The important mechanism behind tumor suppression by 1,3,4-Oxadiazole is related with the inhibition of different growth factors, enzymes and kinases etc. The 1,3,4-Oxadiazole scaffold is a five member heterocyclic…
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Design, synthesis, ADME prediction and anti-hyperglycemic evaluation of new alkoxyimino-substituted phenyl carboxylic acids as potent alpha-glucosidase inhibitors
In an attempt to further explore the role of substituted carboxylic acid derivatives as antidiabetic agent, a series of alkoxyimino-substituted carboxylic acid derivatives (101-206) were designed, synthesized and evaluated for their inhibitory potential against a-amylase and a-glucosidase enzyme. Among all the tested compounds, 102 & 105 has displayed the most potent activity against a-glucosidase with…
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Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice
urn:nbn:sciencein.cbl.2019.v6.115 Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice Published in: Chemical Biology Letters Suman Devi Maharshi Dayanand University Jagjeet Singh Maharshi Dayanand University Vijay Kumar Maharshi Dayanand University Vinay Malik Maharshi Dayanand University Keywords: histopathology, oxidative stress, kidney, lipid peroxidation, toxicology Abstract The present study investigated the effect of monocrotophos,…
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Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity
urn:nbn:sciencein.cbl.2019v6.107 Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity Published in: Chemical Biology Letters Ashish Bhatt Mewar University Krishna Srivastava Shri Ramswaroop Memorial University Ravi Kant Shri Ramswaroop Memorial University Deepa Lakhmani Shri Ramswaroop Memorial University Keywords: 4-methyl-1H-isochromen-1-one, 1,1-biphenyl-4,4-diamine, Antibacterial activity, anti-microbial activity Abstract Selected novel β-lactam and thiazolidinone…
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Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3
urn:nbn:sciencein.cbl.2019v6.113 Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3 Published in Chemical Biology Letters Pooja FNU University of Delhi Nimisha Sinha University of Delhi Sonu Kumar University of Delhi Atul FNU University of Delhi Sumit Kumar University of Delhi Prashant Kumar SRM University Abhishek Pandey University of Delhi Pragya Sharma…
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Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors
Design, synthesis and evaluation of Coumarin-Phenylthiazole conjugates as cholinesterase inhibitors urn:nbn:sciencein.cbl.2019v6.111 Published in Chemical Biology Letters Deepak Mishra Delhi Technological University Atiya Fatima Delhi Technological University Ram Singh Delhi Technological University Nupur S Munjal Jaypee University of Information Technology Vineet Mehta Jaypee University of Information Technology Udayabanu Malairaman Jaypee University of Information Technology Keywords: Alzheimer’s Disease,…
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Chemical libraries targeting Liver Stage Malarial infection
urn:nbn:sciencein.cbl.2019v6.96 Chemical Scaffolds Targeting liver-stage malaria parasite lifecycle Published in: Chemical Biology Letters Neha Sharma Poonam FNU Prakasha Kempaiah Brijesh Rathi University of Delhi Keywords: Malaria, Liver stage, Primaquine, Atovaquone, Clinical trials Abstract Despite the noteworthy advances in the use of chemotherapy for malaria, it continues to constantly affect large number of individuals. New molecules…