Category: Medicinal Chemistry
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Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern
The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variants-…
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Novel Inhibitors of malarial aspartyl proteases, plasmepsin II and IV: In silico design and validation studies
In the dire need of novel inhibitors of enzymes, computational approaches have significantly expedited the drug discovery process. Aspartic protease enzymes of Plasmodium falciparum such as plasmepsin II (PfPlm II) and plasmepsin IV (PfPlm IV) have been recognized as an attractive drug target for antimalarial drug discovery. In line with this, we performed high-throughput screening…
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A comprehensive review on therapeutic properties of Mustard Oil and Olive Oil
Plants and their extracts have been extensively studied for their efficacy in therapeutic applications. Their Essential Oils (EOs) are responsible for the majority of biological properties such as anticancer, antibacterial and antimicrobial, antioxidant, anti-inflammatory, and cardio-protective. The utilization of natural compounds is gaining a lot of attention these days. These oils act as natural alternatives…
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Journal of Molecular Chemistry
Journal of Molecular Chemistry is an ideal home for Chemistry research advances in Organic Chemistry, Catalysis, Polymer Chemistry, Medicinal Chemistry, Materials Chemistry, Green Chemistry, Environmental Chemistry and Applied Chemistry.
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Molecular Chemistry Letters
Molecular Chemistry Letters is a lead journal of Chemistry research in Organic Chemistry, Catalysis, Polymer Chemistry, Medicinal Chemistry, Materials Chemistry, Green Chemistry, Environmental Chemistry and Applied Chemistry.
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Clinical status of potential drugs used for COVID-19 treatment and recent advances in new therapeutics – A review
COVID-19, a perilous disease caused by SARS-CoV-2, has brought a massive damage to humankind, and turned into a global catastrophe. It was first reported in Wuhan, China in December 2019 and since then has been a constant source of worry for the scientists and the medical world, due to the carnage it has caused globally.…
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A comparative study of isothermal nucleic acid amplification methods for SARS-CoV-2 detection at point-of-care
COVID-19, caused by the novel coronavirus SARS-CoV-2, has put most of the world under lockdown. Despite approved vaccines, COVID-19 cases, hospitalizations, and deaths have remained on the rise. Rapid diagnosis and necessary public health measures are still key parts to contain the pandemic. Here, the colorimetric isothermal nucleic acid amplification tests (iNAATs) for SARS-CoV-2 detection…
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Testosterone in the pathogenesis of tuberculosis
Tuberculosis is a leading cause of death from infectious diseases worldwide with more than 1.5 million deaths occurring annually. Males have been known to be more susceptible to tuberculosis than females. Sex hormones could be an important factor governing this gender bias. Here, we discuss the evidence that testosterone may be a crucial factor in…
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Resistin and visfatin: ‘connecting threads’ of immunity, energy modulations and male reproduction
Adipokines, mostly produced by white adipose tissues, have been established to be endocrine factors which are also essential in energy homeostasis. More recently, their contribution in fertility regulation has been recommended. Resistin as well as visfatin are unique adipocyte-derived signaling chemicals whose expressions enhance in advanced obesity and are implicated in insulin resistance as well…
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Immunoendocrine regulation of energy homeostasis and male reproduction
Human reproductive system involve a number of intricate complex interconnected physiological metabolic pathways and metabolites with involvement of overall health of different body organs. Overall health alterations mediated physiological conditions such as obesity, diabetes etc. bring about additional variations in expression and presence of metabolic constituents including kinases, hormones, proteins, peptides. The detailed analysis of…