Chemistry and Biology of Coenzyme F420 in Tuberculosis treatment

Abstract

Coenzyme F₄₂₀ is one of the ancient and rare coenzymes in biology. The unique electrochemical properties of F₄₂₀ are compared with the ubiquitous flavin coenzymes FMN (flavin mononucleotide), FAD (flavin adenine dinucleotide), and nicotinamide coenzyme NADP+ (nicotinamide adenine dinucleotide phosphate). The role of F₄₂₀ in the reductive activation of pretomanid and delamanid is used in the treatment of tuberculosis. The F₄₂₀ is also involved in cell wall biosynthesis and reductive activation of the heme degradation pathway in M. tuberculosis, which contributes to the development of new drugs for the treatment of tuberculosis.

URN:NBN:sciencein.cbl.2022.v11.666