1,5-Benzothiazepine: Bioactivity and targets

Benzothiazepine

Authors

  • Rajneesh Kaur Maharishi Markandeshwar University
  • Raman Singh Maharishi Markandeshwar University
  • Kuldeep Singh Maharishi Markandeshwar University

Abstract

1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets for 1,5-benzothiazepine nucleus to establish structural activity relationship. It is an attempt to compile account of various structural modification in 1,5-benzothiazepine scaffold as reported for their versatile biological activities. This review would provide a platforms for selection of suitable moieties and development of specific chemical entities with desired features.

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Author Biography

  • Rajneesh Kaur, Maharishi Markandeshwar University

    Department of Chemistry

Published

2016-04-22

Issue

Section

Review Articles

How to Cite

(1)
Kaur, R.; Singh, R.; Singh, K. 1,5-Benzothiazepine: Bioactivity and Targets. Chem Biol Lett 2016, 3 (1), 18-31.

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