Inhibitory effects of reserpine against efflux pump activity of antibiotic resistance bacteria

antibiotics resistance


  • Sridevi Dhanarani Bharathidasan University
  • Shankar Congeevaram CVR - Labs Pvt. Ltd
  • Prakash Piruthiviraj Bharathidasan University
  • Joon Hong Park Yonsei University
  • Thamaraiselvi Kaliannan Bharathidasan University


Antibiotic resistant bacteria (ABR) is an alarming issue and it has to be eliminated before enter into the environment.  The role of efflux pump inhibitor, reserpine – a plant alkaloid in reducing the antibiotic resistance in Staphylococcus sp., Streptococcus sp. and Micrococcus sp. from poultry litter were evaluated.  Reserpine increased the activity of antibiotics against bacteria and directly blocks the antibiotic efflux pump.  Resistances of bacteria to antibiotics were reduced when they were grown in the presence of reserpine.  Furthermore, this compound effectively reduced the Minimum Inhibitory Concentration (MIC) of several antibiotics such as ampicillin, erythromycin, tetracycline, chloramphenicol, streptomycin, kanamycin, rifampicin and tobramycin, suggesting that reserpine are representatives of bacterial efflux inhibitors with the potential application in combination therapy for veterinary medicines.   This defensive action will helps us to reduce the existence of ABR in poultry industry as well as in the environment.


Download data is not yet available.

Author Biographies

  • Sridevi Dhanarani, Bharathidasan University

    Tiruchirappalli, Tamil Nadu

  • Shankar Congeevaram, CVR - Labs Pvt. Ltd

    Chennai, Tamil Nadu

  • Joon Hong Park, Yonsei University

    School of Civil and Environmental Engineering, Yonsei University, Seoul 120-749, South Korea






How to Cite

Dhanarani, S.; Congeevaram, S.; Piruthiviraj, P.; Park, J. H.; Kaliannan, T. Inhibitory Effects of Reserpine Against Efflux Pump Activity of Antibiotic Resistance Bacteria. Chem Biol Lett 2017, 4 (2), 69-72.