Author: ScienceIn

urn:nbn:sciencein.cbl.2019v6.97

Published in: Chemical Biology Letters

• P.J. Bindu Kuvempu University
• T. R. Ravikumar Naik Indian Institute of Science
• K.M. Mahadevan Kuvempu University
• G. Krishnamurthy Sahyadri Science College

Keywords: Anti-oxidant, photodynamic therapy, DNA-Drug, tetrahydroquinolin

Abstract

2-Methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-ones (3a−g) were synthesized by one pot multicomponent aza Diels-alder reaction between N-arylimines with two molecules of N-vinyl-2-pyrrolidinone in presence of Sm(III)nitrate as catalyst in acetonitrile solvent at room temperature stirring. The photocleavage studies with 2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-ones (3a−g) revealed that almost all derivatives exhibited effective photocleavage of pUC−19 DNA at 365 nm, The The anticancer activities of newly synthesized compounds (3a−g) were more potent than doxorubicin on MCF−7 cells. The docking of PBR receptor (1EQ1) protein with newly synthesized THQ’s (3a-g) exhibited well established bonds with one or more amino acids in the receptor active pocket.

How to Cite Bindu, P., Naik, T. R. R., Mahadevan, K., & Krishnamurthy, G. (2019). Synthesis, DNA photocleavage, molecular docking and anticancer studies of 2-methyl-1,2,3,4-tetrahydroquinolines. Chemical Biology Letters, 6(1), 8-13.

Retrieve Full text from http://pubs.thesciencein.org/journal/index.php/cbl/article/view/7

by Prof. Anant Hardas

Published in Journal of Biomedical and Therapeutic Sciences BiomedFrontiers section (Print)

The first issue of Pharmacy Journal in India – The Indian Journal of Pharmacy was published in Dec 1894, however it was defunct after 3 years. The Modern Pharmaceutical Journalism in India was Pioneered by Mr. Premnath Bazaz, who started the Eastern Pharmacist in 1958 and equal contribution was by Dr. A.K. Patni, who edited Indian Drug since its inception published by IDMA. Today there are nearly 175 Pharmacy Journal published in mostly English (and also in Marathi, Hindi & Bengali) by 5 different categories of publishers in India. The PCI has set out official Journals – seven – for D. Pharm Course and 20 for B. Pharm Degree Course, and minimum 2 international Journals for each discipline of specialization at M. Pharm, Ph.D and Pharm. D Courses structure in India. This article brings out short History and progress of Indian Pharmacy Periodical as on today.

urn:nbn:sciencein.jmns.2019v6.94

Improved electrochemical performance of free standing electrospun graphene incorporated carbon nanofibers for supercapacitor

Published in Journal of Materials NanoScience

• Dipti V Jamkar Rashtrasant Tukadoji Maharaj Nagpur University
• Balkrishna J. Lokhande Solapur University
• Subhash B. Kondawar Rashtrasant Tukadoji Maharaj Nagpur University

Keywords: Carbon nanofibers, graphene, electrospinning, electrochemical performance, supercapacitor

Abstract

In this paper, we report the fabrication of carbon nanofibers (CNFs) by electrospinning of polyacrylonitrile (PAN) solution in N,N-dimethylformamide (DMF)with different concentrations followed by stabilization and carbonization in a tubular quartz furnace. To improve the electrochemical performance, graphene nanosheets have been used to prepare porous graphene/carbon nanofibers (G-CNFs). The morphology of the porous G-CNFs were characterized by means of scanning electron microscopy (SEM). Diameter of CNFs and G-CNFs were found to be in the range of 400 – 500 nm reveals the fibers in nanoscale with high porosity. The electrochemical performance of as-synthesized CNFs and G-CNFs was studied by cyclic voltammetry (CV), galvanostatic charge discharge (GCD) and electrochemical impedance spectroscopy. The CV curve of the pure CNFs show distorted rectangular shape whereas CV curve of G-CNFs exhibit a nearly rectangle-shaped profile which is the characteristic of an ideal electric double-layer capacitor. The improved electrochemical performance of G-CNFs is due to the improved internal electrical conductivity of G-CNFs via graphene nanosheets interlaying.

Jamkar, D., Lokhande, B., & Kondawar, S. (2019). Improved electrochemical performance of free standing electrospun graphene incorporated carbon nanofibers for supercapacitor. Journal of Materials NanoScience, 6(1), 32-37.

Retrieved full text from https://pubs.thesciencein.org/journal/index.php/jmns/article/view/94

The instruction for converting your manuscript into journal article template is provided in the video below. The instructions are common and same for all journals published by ScienceIn.

Recent advances in metal nanoparticles supported on Montmorillonite as catalysts for organic synthesis

urn:nbn:sciencein.jmns.2019v6.87

Published in Journal of Materials NanoScience

• Dipak Kumar Dutta
  CSIR-North East Institute of Science and Technology, Materials Sciences and Technology Division, Jorhat 785006, Assam

Keywords: Metal-Nanoparticles, Supported Catalysts, Heterogeneous Catalysts, Organic Synthesis

Abstract

Nanostructured materials has appealed considerable attention due to their characteristic properties and applications in different fields. Metal nanoparticles supported on modified montmorillonite composites have led to the generation of new and novel heterogeneous ‘Nanocatalysts’, which are much more efficient than other catalysts and thus pave the way for developing sustainable environmentally benign catalysis and chemical procedures. Such nanocatalysts are progressing towards their use in chemical industries. This review presents the recent trend of advances in the synthesis and catalytic reactions of supported metal nanoparticles on acid activated montmorillonite. Metals nanoparticles-montmorillonite composites show efficient catalytic activities with high conversions and selectivity for hydrogenation, transfer hydrogenation, oxidations and coupling reactions. Raw montmorillonite possess no catalytic activity, however acid activated montmorillonite exhibits excellent acid catalytic activities.

Dutta, D. (2019). Recent advances in metal nanoparticles supported on Montmorillonite as catalysts for organic synthesis. Journal of Materials NanoScience, 6(1), 19-31.

Retrieve full text from https://pubs.thesciencein.org/journal/index.php/jmns/article/view/87

urn:nbn:sciencein.cbl.2019v6.93
Formulation optimization of multicomponent aqueous coground mixtures of Meloxicam for dissolution enhancement
Multicomponent coground mixtures of meloxicam

Published in Chemical Biology Letters

• Sunita Dahiya University of Puerto Rico
• Atul Kaushik
• Kamla Pathak

Keywords: factorial design, solubility, drug delivery, hyrophilicity, PEG

Abstract

In present work, the role of various formulation excipients for dissolution enhancement of a BCS Class II drug, meloxicam was studied by formulating multicomponent aqueous coground mixtures using lactose, microcrystalline cellulose and three solubilizers; polyethylene glycol 400, propylene glycol and polyvinyl pyrrolidone. A 3³ full factorial design was employed using solubilizers’ concentrations as independent variables whereas angle of repose and in vitro drug dissolution as dependent variables in order to optimize the amounts of solubilizers. The results revealed more than fivefold increase in drug dissolution in some experimental batches compared to that of pure drug powder. Full and reduced models were evolved for the dependent variables and the reduced models were further validated using extra design check points. The studies suggested that the incorporation of optimized amounts of solubilizers could be successfully employed for achieving desired flow properties and enhanced drug dissolution of poorly water soluble meloxicam. The method emerged as a simple, cost-effective, and organic solvent-free green approach toward formulation development of meloxicam and may also be applied to other limited water-soluble drugs.

Dahiya, S., Kaushik, A., & Pathak, K. (2019). Formulation optimization of multicomponent aqueous coground mixtures of Meloxicam for dissolution enhancement. Chemical Biology Letters, 6(1), 1-7.

Full text link https://pubs.thesciencein.org/journal/index.php/cbl/article/view/93

The interaction and properties of light and heat with nanomaterials has brought new insights in the field of nanotechnology and nanoscience development. The recent advances of Photonics and Phononics of nanomaterials in form of research and review articles as thematic coverage of field to enlighten the knowledge of scholars span the subfield (though not limited to):

Nanophotonics of natural materials

Principles of nanophotonics

Near Field Optics Advances

SERS of 2D nanomaterilas

Computational nanophotonics

Static state computation of nanomaterials

Plasmonics

Metamaterials

Optical processor and chip development

Molecular nanophotonics

Tip Enhances Raman Spectroscopy TERS of 2D materials

Hybrid Nanophotonics

Fabrication of Nanophotonics

Nanophotonic Bioimaging

Nanophotonics Therapy

Chemistry of nanophotonics and nanophononics

Nanophotonics fluidic applications

Nanophotonics of metalic nanoparticles

Colloidal particle engineering

photonics crystals

lithography

How to submit

The manuscript should be submitted online on the journal site (select Nanophotonics and Nanophononics section during submission) at https://pubs.thesciencein.org/journal/index.php/jmns . The author guidelines and manuscript template is provided on the journal site.

Last date of submission: Submission ongoing

urn:nbn:sciencein.jbts.2019v6.90

Antidiabetic effect of Carissa carandas in rats and the possible mechanism of its insulin secretagogues activity in isolated pancreatic islets

• Rambir Singh Bundelkhand University
• Mansi Shrivastava Bundelkhand University
• Poonam Sharma Indira Gandhi National Tribal University

Keywords: Antidiabetic, Solvent Extract, Insulin, Plant fruits, phytochemicals, diabetes

Abstract

Carissa carandas (CC) has been used in folklore medicine for treatment of diabetes. In the present study, hexane, chloroform, ethyl acetate, methanol and aqueous extracts of CC fruit were examined for hypoglycemic activity in healthy Wistar rats. Aqueous Extract of CC (AECC) was most active and showed fall of 67.08% in fasting blood glucose from 0 to 1h in glucose tolerance test (GTT). The ED₅₀ of AECC was 300mg/kgbw in streptozotocin induced diabetic rats. Treatment of diabetic rats with ED₅₀ of AECC for 28 days significantly reduced post prandial glucose (PPG) by 33.65% (p<0.01), glycosylated hemoglobin (HbA1c) by 45.79% (p<0.01) and increased insulin level by 69.7% (p<0.05). The results indicated that increase in insulin secretion may be partly responsible for antidiabetic effect of AECC. To assess the mechanism of secretagogues activity, AECC was incubated with isolated pancreatic islets of healthy Wistar rats at basal (3.3mM) and high (16.7mM) level of glucose in presence or absence of Diazoxide (K-ATP channel opener), Nimodipine (Ca²⁺ Channel blocker) and Calphostin-C (PKC inhibitor). AECC induced insulin secretion at 16.7mM of glucose was significantly (p<0.01) reduced by Diazoxide and Nimodipine but non significantly (p>0.05) by Calphostin-C. The study indicated that the phytochemicals present in AECC may be inducing insulin secretion by closing K-ATP channels in β-cells of pancreatic islets.

Full text link: https://pubs.thesciencein.org/journal/index.php/jbts/article/view/90

urn:nbn:sciencein.jmns.2019v6.88

Nanochemistry and Nanocatalysis Science: Research advances and future perspective

Bhupender S. Chhikara, Rajender S. Varma

The development of nanomaterials has made its mark in nanocatalytic applications and ensuing plethora of nanotechnological advances. The size-dependent chemistry of nanomaterials and consequent controlled and designed synthesis of smart materials with desired end application has provided us a number of new products recently which are already making impact on quality of human life. The fundamental nano paradigm shift would influence future research advances in field of nanoscience chemistry, ranging from drug delivery to exquisite designs of novel catalysts that drive innovations in chemical synthesis and transformations.  The nanoscience is an interdisciplinary field that will see increased role in the diverse and emerging newer areas like artificial intelligence; nanochemistry would help speed up the development of applications in the real world with artificial intelligence.

Full text link: https://pubs.thesciencein.org/journal/index.php/jmns/article/view/88

It is a pride moment for ScienceIn family, editors, scientists and researchers that Dr. Rajender S Varma, the editor of JMNS and emeritus scientist, Environmental Protection Agency, USA has been awarded Haryana Vigyan Ratan Award (translation: Haryana Science Jewel Award) 2017 on February 28, 2019 at Haryana Raj Bhawan, Chandigarh. Dr. Varma has been given this recognition for his enormous research contribution in Green Chemistry, Catalysis, NanoScience-nanomaterials, nanochemistry, nanocatalysis. Prof. Rajender (Raj) S. Varma did Ph.D. from Delhi University in 1976. He is Editor of Journal of Materials NanoScience, advisory board member of several international journals and has published over 470 scientific papers and awarded 16 US Patents, 8 books, 27 book chapters and 3 encyclopedia contributions with over ~ 31,000 citations. He is highly accomplished researcher with high citations to his work having H -Index 96. Dr. Varma hail from a village in haryana (now in punjab). On receiving the award he said “It is a proud moment for a country boy”. It is a highest award from state government for scientists.

The Department of Science and Technology Haryana Government has instituted a highest honour for the contributions in field of scientific research with title “Haryana Vigya Ratan” to honor and acknowledge the contributions of researchers from Haryana and “Haryana Yuva Vigyan” Award for the recognition of young scientists.

Dr. Varma is editing a special section/issue on Nanochemistry and Nanocatalysis , researchers working in the field can contribute their research findings (research articles or review articles ) for consideration in the special section of the journal. More details available on Dr. Varma’s Nanochemistry special section Editor.