Recent trends in synthetic Top-down approach for Mesoporous Carbon: A seminal review

This review is focused on the different synthetic methods of mesoporous carbon for exotic applications. In the 21st century, doped carbon nanostructures and composites have cutting-edge applications in materials sciences due to their superior physicochemical properties. Porous carbon has enticed material scientists because of its excellent properties like ordered porous structure, tunable pore size, and high specific surface area. As a result, the extensive studies on the synthesis and modification of mesoporous carbon are being performed. The most enticing approaches for synthesis of ordered mesoporous carbon are hard template and soft template methods. On the other hand, non-templating pathways are equally important to synthesize mesoporous carbon as that are templating pathways. This report includes details of different synthetic methods for synthesis of mesoporous carbon materials by templating as well as non-templating methods.

URN:NBN:sciencein.jmns.2023.v10.601

Recent trends in synthetic Top-down approach for Mesoporous Carbon: A seminal review – https://pubs.thesciencein.org/journal/index.php/jmns/article/view/a601

Journal of Materials NanoScience

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies

Chemical warfare agents, especially organophosphorus (OP) compounds, are known for their extreme toxicity causing inhibition of acetylcholinesterase (AChE) enzyme activity due to covalent phosphorylation. This leads to functional impairment of muscarinic nicotinic acetylcholine receptors, resulting in severe ill effects that ultimately lead to death. For OP poisoning, AChE reactivators play a crucial role in the treatment process. Among several AChE reactivators, Oxime reactivators are majorly employed for the treatment of OP intoxication, nevertheless, these are associated with certain drawbacks such as their toxic effects, low blood-brain barrier (BBB) penetration, less reactivation in the central nervous system (CNS), and inefficiency toward all nerve agents, and blocked AChE. As a result, new therapeutic strategies are required. Recent attempts are focused on the design and synthesis of uncharged oximes or non-oxime reactivators which can overcome the limitations of oxime-based reactivators. A novel class of non-oxime reactivators is gaining interest, including compounds like Mannich phenols, chloroquines, and some general bases. This review is a novel attempt to incorporate various possible oxime and non-oxime AChE reactivators for OP intoxication along with their in vitro, in vivo, and in silico studies.

URN:NBN:sciencein.cbl.2023.v10.538

Role of Acetylcholinesterase (AChE) reactivators in the treatment of Organophosphorus poisoning: in vivo, in vitro, and in silico studies – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/538

Chemical Biology Letters

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol

Plants serve as an excellent source of therapeutic molecules that help in medicinal treatments. The production of large amounts of pure phytocompounds from plant sources for human consumption and the nature of phytocompounds exhibiting toxicity issues at higher dosages lead to the challenge of increasing the therapeutic effect by using low dosages. This current study focuses on extracting two active antioxidant compounds, quercetin (Q) and resveratrol (R), from plant sources and evaluating their ability to exhibit antioxidant synergism through in vitro models. Quercetin and resveratrol were extracted using an ethanol-solvent extraction procedure from Allium cepa, and Vitis vinifera peels, respectively. The extracts were subjected to qualitative and quantitative analysis, column chromatography and then High-Performance Liquid chromatography for purification. DPPH, ABTS+, SOS, and cellular antioxidant assays evaluated the synergistic antioxidant activity of the quercetin and resveratrol complex. The results showed synergistic antioxidant efficacy values approximately as follows: 5.37 % in DPPH, 15.26 % in ABTS+, 11.99 % in SOS, and 19.13 % in cellular antioxidant assays when both molecules were used combinedly. The results promisingly pave the way for a new dimension in nutraceuticals formulation parameters which could trigger combined molecular usage to achieve better results at low dosages.

URN:NBN:sciencein.cbl.2023.v10.534

In-vitro evaluation of synergism in antioxidant efficiency of Quercetin and Resveratrol – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/534

Chemical Biology Letters

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis

Targeting of epidermal growth factor receptors (EGFRs) and vascular endothelial growth factor receptors (VEGFRs) has become a major strategy for the control of head and neck cancer. c-MET, a receptor tyrosine kinase is known to be expressed in many cancers including the head and neck squamous cell carcinoma (HNSCC). The c-MET activity has been correlated with many signaling pathways that help the cancer cells to proliferate, migrate and invade into the normal, healthy tissues. The association of c-MET with glycolytic pathway in HNSCC has not been elucidated yet. Since, increased glycolysis has emerged as a major hallmark for cancer cell proliferation, targeting c-MET could bring an impact to inhibit HNSCC progression. In the present study we use various In-silico tools available to identify the association of c-MET with the major metabolic genes such as HK-II (Hexokinase-II), GLUT-1 (Glucose transporter-I), LDH-A (Lactate dehydrogenase-A), PFK-II (Phosphofructokinase-II) and MCT-1 (Monocarboxylate transferase-1) in HNSCC patient datasets available from The Cancer Genome Atlas (TCGA). Protein networking analysis was used to determine the correlation of c-MET with the metabolic genes. Retrieved sequenced data pathway analysis gives the network of genes associated in the activation of glycolytic pathway. Gene ontology and Enrichr studies provide an insight into c-MET activity in metabolism through molecular, functional and pathway basis in HNSCC. Furthermore, we also have shown a negative correlation of c-MET with immune cell infiltration, suggesting c-MET might have a role in immune suppression in HNSCC patients. Further validation on this study could possibly make c-MET as a potential target to inhibit HNSCC.

URN:NBN:sciencein.cbl.2023.v10.532

Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/532

Chemical Biology Letters

New Drug Delivery Review Article 2022, 2023

The drug delivery is an important factor now in rationalization of any new or existing drug towards specific ailment, the most prominently against the cancer where drug delivery systems have been extensively explored. The new advancement in drug delivery using different nano-particular systems viz. metal nanoparticles, liposomes, dendrimers, lipids, carbon nanomaterials, niosomes, phytosomes, virus, and other systems are moving towards the precision drug delivery.

All different aspects towards a precise drug delivery have been discussed in a recent review article that has been published in the ‘Applied NanoMedicine’. Readers can access the article PDF at:

The above article should also serve your queries related to drug delivery article 2023; drug delivery article 2022; new drug delivery systems; precise drug delivery; gene delivery article 2022; recent advances in drug delivery; advanced drug delivery reviews; journal article; drug delivery review PDF; Drug delivery systems updated review – PMC – NCBI; commercial drug delivery technologies; current research in drug delivery; precision nanoparticles for drug delivery – Nature; drug delivery review article; new drug delivery methods; drug delivery system pdf; drug delivery systems examples; importance of drug delivery system; Novel drug delivery system review article and related queries.

Authors can publish similar articles related to drug delivery research in the journal ‘Applied Nanomedicine‘ , the submission details, template and journal information is provided on the link

https://pubs.thesciencein.org/journal/index.php/nanomed

Oxidative stress and antioxidants in reproductive health and disorders – Special Issue

Infertility affects 15% of couples worldwide and is a major health issue. One of the primary reasons for infertility is oxidative stress (OS), which is defined as an imbalance in the amounts of reactive oxygen species (ROS) and antioxidants. In case of male reproduction, physiological functions of sperm, especially capacitation, hyperactivation, and acrosomal reaction, require a modest level of ROS. However, excessive ROS generation can inactivate vital enzymes and oxidize proteins in spermatozoa, lipid peroxidation or DNA damage, leading to infertility. Major sources of ROS include immature spermatozoa, inflammatory agents, genetic mutations, and altered sex hormone levels. In case of female reproduction, existing literature suggest that ROS affect oocyte development, maturation, follicular atresia, corpus luteum function, and luteolysis. Mechanisms of OS-mediated female reproductive tract disorders resemble those of male infertility to a substantial extent. Since OS is caused by deficiency in antioxidants, adopting a healthier lifestyle and taking antioxidant supplements are used as conventional treatment for OS-mediated infertility.
This special issues aims to highlight the physiological ROS generation, genetic and epigenetic influences on OS and infertility; and also to present an updated in-depth insight on the mechanism involved in OS-induced infertility, including lipid peroxidation, DNA damage, hormone profile imbalance, inflammation, etc. Finally, the special issue intends to discuss the beneficial impacts and limitations of using antioxidants in treating male and female infertility.

Themes:
Potential topics include but are not limited to the following:
● Oxidative stress in male and female infertility
● Systemic diseases and reproduction: oxidative stress as the key player
● Endocrine disruption, oxidative stress and reproduction
● Infection, inflammation and oxidative stress in reproductive pathophysiology
● Antioxidants in the mitigation of oxidative stress induced reproductive disorders

Editors

Dr Pallav Sengupta and Dr. Sulagna Dutta

 Important Dates

Full Article Submission date- April 15, 2023
Issue completion date – June 1, 2023

Submission

Interested scholars should submit their article (prepared according to author guidelines in the journal article template) on the journal site https://pubs.thesciencein.org/journal/index.php/jist 

Authors should submit their article manuscript directly to guest editors for preliminary editorial processing.

Participating Journal

Journal of Integrated Science and Technology

http://pubs.thesciencein.org/journal/index.php/jist

Journal of Molecular Chemistry – Impact factor, indexing and related matrices

Journal of Molecular Chemistry . Impact Factor*

2.4

Journal Journal of Molecular Chemistry
ISO 4J. Mol. Chem.
TypePeer Reviewed, International
Editorial BoardMultinational [Link]
DisciplineOrganic Chemistry, Catalysis, Polymers, Peptides, Macromolecules, Medicinal Chemistry, Materials Chemistry, Inorganic Chemistry, Molecule design, synthesis, and applications.
LanguageEnglish
Article typeResearch Article, Review Article,
Short Communications, Editorial

Submit your article at Journal site:
https://pubs.thesciencein.org/journal/index.php/jmc

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 4-Jan-2023

Indexed In

Google ScholarLink: https://scholar.google.com/scholar?as_vis=1&q=source:Journal+source:Molecular+source:Chemistry&hl=en&as_sdt=1,5

Google Scholar Citations : JMC on Google Scholar

Applied Nanomedicine – Impact factor, indexing and matrices info

Applied Nanomedicine Journal . Impact Factor*

4.4

Journal Applied NanoMedicine
ISO 4Appl. NanoMed.
TypePeer Reviewed, International
Editorial BoardMultinational [Link]
DisciplineNanoMedicine, Nanobiotechnology, Biomedical Nanotechnology, Nanomedical Sciences, Drug Delivery, Nanotheranostics, Nanotherapy, Nanodiagnosis, Nanopharmaceuticals
LanguageEnglish
Article typeResearch Article, Review Article,
Short Communications, Editorial

Submit your article at Journal site:
https://pubs.thesciencein.org/journal/index.php/nanomed

#Citation Source: Google Scholar for IF (interim) Calculations. *Citation recorded as on 4-Jan-2023

Indexed In

Google ScholarLink: https://scholar.google.com/scholar?as_vis=1&q=source:Applied+source:Nanomedicine&hl=en&as_sdt=1,5

Google Scholar Citations : Applied Nanomedicine on Google Scholar
Nanomedicine Journal

Scopus indexing of the article published in the ScienceIn Journals

The Scopus indexing of the articles published in the ScienceIn Journals is a frequent query by the different publishing authors. The ScienceIn journals are peer reviewed international multidisciplinary journals meant for publication of quality research advances in different fields of science (Chemistry, Biology, Biotechnology, Pharmaceuticals Sciences, Physics, Materials Sciences, Environmental Science ) and technology fields (all engineering sub-disciplines).

The following ScienceIn journals have been evaluated by Scopus board (Scopus Content Selection & Advisory Board (CSAB)) and accepted for indexing in Scopus database. As a large number of queries arise from researchers regarding the indexing of journal contents in Scopus and other databases, this document has been made available to provide the answer to FAQ about indexing of Journal contents.

Scopus indexed ScienceIn journals are

Chemical Biology Letters
Journal of Integrated Science and Technology

FAQ and response for indexing of the articles are:

When my article published in CBL/JIST will be indexed by Scopus?

The Scopus content indexing support team continuously and periodically indexes the articles, however, we can’t provide an exact time for indexing, it may take upto 6 months or more/less depending upon when the Scopus team keeps the next round of indexing of respective journal contents.

My article published in JIST/CBL has not been indexed in Scopus while other articles from the year/volume are listed in Scopus?

You may contact the Scopus support for inclusion of your missing article/content. The details of procedure is provided on Scopus/elsevier page (click to see, use the form provided in step 2 to add your article in Scopus database).

My article is missing in Scopus listing ?

Please refer previous question.

Can I, as Author, approach the Scopus to include/index my article published in JIST / CBL as my University/Institute requires the inclusion of my article in Scopus.

You may wait for some time as Scopus team will add the contents/articles themselves, however, for urgency you may use the link/form details on Scopus site (on Scopus/elsevier page link).

————————————————

Regioselective synthesis of indole-thiazolidine-2,4-dione coupled isoxazoles as in vitro tubulin polymerization inhibitors

Regioselective synthesis of indole-thiazolidine-2,4-dione coupled isoxazoles as in vitro tubulin polymerization inhibitors

Herein we synthesized new indole-thiazolidine-2,4-dione coupled isoxazoles (7a-n) via simple reactions like N-propargylation, Knoevenagel condensation and copper (I) catalysed one pot regioselective reactions. All the newly synthesized compounds were characterized by 1H-NMR, 13C-NMR and Mass spectra and they were screened for in vitro anticancer activity against three human cancer cell lines like A549 (lung), MCF-7 (breast), and SKOV3 (ovarian) using MTT assay and etoposide was used as the standard drug. As per the results the compounds 7e, 7f and 7g where shown selectivity towards A549 cell line with IC50 values of 5.27 µM, 3.14 µM and 6.25 µM respectively and they are high active than etoposide. Further in vitro tubulin polymerization assay on three potent compounds (7e, 7f and 7g) revealed that compounds 7e and 7f have exhibited potency than standard combretastatin A-4 with IC50 values 0.82 and .044 mM respectively.

URN:NBN:sciencein.cbl.2023.v10.531

Regioselective synthesis of indole-thiazolidine-2,4-dione coupled isoxazoles as in vitro tubulin polymerization inhibitors – https://pubs.thesciencein.org/journal/index.php/cbl/article/view/531

Chemical Biology Letters