Synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives of acid sensitive aldehydes catalyzed by lanthanum nitrate in ionic liquids

Abstract

Synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives (4a-f) of acid sensitive aldehydes catalyzed by lanthanum nitrate in ionic liquids is described. The method offers use of inexpensive, readily available and efficient Lewis acid catalyst in an environment benign process with excellent yields in short reaction time and easy product isolation with high purity.