Applied NanoMedicine
https://pubs.thesciencein.org/journal/index.php/nanomed
<p>The journal publishes research advances in field of nanomedicine and nanobiotechnology covering the following subtopics:</p> <p>Clinical Nanomedicine, Targeted and stimuli-responsive drug delivery, Ultrasensitive biosensing and in vitro diagnostics, Multimodal in vivo bioimaging, Nanotheranostics, Nanoradiopharmaceuticals, Tissue engineering and regenerative medicine, Nanotoxicology, Emergency nanomedicine, Nanoformulation of natural products, Nanodrugs and drug target interactions, Non-viral gene therapy, Nanorobotics, Ethical and policy aspects related to nanomaterials, Nanomaterials in food with possible medical effects. All fields of Nanobiotechnology, Nanomedicine, Nanobiomedical Sciences are covered by the journal.</p>enApplied NanoMedicineEvaluation of sensing ability of aptamers towards β-casomorphin-7 (BCM-7) peptide in different assay formats
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/554
<p>Aptamers are useful ligand molecules for the recognition of target molecules. Aptamers, as well as target molecules, are modified for their use in developing assay protocols for targets. Assay format uses gold nanoparticles or magnetic beads or 96-well plate or membrane surface for interaction between aptamer and target molecules. The present investigation is aimed to evaluate the recognition potential of modified aptamers towards β-casomorphin-7 (BCM-7) peptide. Aptamers (Seq.7 and Seq.U5) selected in previous work for BCM-7 as well as their variable regions and selected truncated segments of variable regions were evaluated for recognition of BCM-7. Aptamers or biotinylated aptamers or amino group attached to aptamer and BCM-7 or biotinylated BCM-7 or BCM-7-peroxidase were used in different assay geometry using streptavidin-coated gold nanoparticle or streptavidin-coated magnetic beads or streptavidin-coated 96-well plate or nitrocellulose & nylon membranes. In different assay formats, biotinylated full-length aptamers (Seq.7 and Seq.U5) as well as biotinylated variable region of aptamer Seq.U5 (Seq.U5v) recognized BCM-7. However, truncated aptamers from Seq.U5v failed to recognize BCM-7. Assay formats using aptamer-BCM-7 interaction can be adapted for studying aptamer-target recognition. Seq.7 and Seq.U5 are promising aptamers for developing protocols in different assay geometry for measuring BCM-7 in the urine sample.</p> <p><em>URN:NBN:sciencein.nanomed.2023.v3.554</em></p>
Articlesaptamersgold nanoparticlesmagnetic beadsaptasensorsbiosensingbeta-casomorphin peptidepeptide recognitionAbhishek ParasharVanya BhushanNimai Charan MahanandiaAshok Kumar MohantySudarshan KumarRajan SharmaYudhishthir Singh Rajput
Copyright (c) 2022 Abhishek Parashar, Vanya Bhushan, Nimai Charan Mahanandia, Ashok Kumar Mohanty, Sudarshan Kumar, Rajan Sharma, Yudhishthir Singh Rajput
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2022-12-212022-12-21554554Recent trends in precision drug and gene delivery
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/429
<p>Delivery is the key to the proper functioning of a system—be it in a social network or a living organism. Imagine your groceries getting delivered to your office or the birthday gift you ordered for your dear ones doesn't reach you on time. Similarly, the payload must be timely delivered to the target biological sites for function, prevention, and cure. Thus, precision delivery has been one of the prime focuses of research. Over the decades, researchers have developed many efficient delivery systems for a diverse set of payloads like drug molecules, genes, nutrients, diagnostic probes, engineered cells, or nanorobots. Here we discuss the recent advancement in precision drug and gene delivery for various biological applications.</p> <p><em>URN:NBN:sciencein.nanomed.2022.v2.429</em></p>
EditorialDrug deliveryGene deliveryPrecision medicinetargeted therapyGene therapyliposomessolid lipid nanoparticlesnanoparticlesAntibody-drug conjugatesPolypeptidesRNA deliveryDNA nanodevicesSadiya TangaBasudeb Maji
Copyright (c) 2022 Sadiya Tanga, Basudeb Maji
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2022-09-142022-09-14429429In vivo sojourn of DNA nanodevices: Taking stock of the past and perspective for future challenges & applications
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/337
<p>DNA based nanotechnology has witnessed phenomenal advances in biomedical applications such as drug delivery, bio imaging and bio sensing. Designer DNA nanodevices are at the forefront of many technological breakthroughs in modern science. An emerging class of programmable DNA nanodevices offer unique and powerful approaches for targeted drug delivery <em>in vivo</em> with minimal toxicity. The potential advantages of DNA nanostructures have ensured a bright future of DNA based nanodevices for almost all the domains of biomedical applications. This review integrates fundamental aspects of DNA nanotechnology and delineates the recent advances in therapeutics and <em>in vivo</em> targets of designer DNA nanostructures. It specifically discusses the history of the DNA nanotechnology origin, building of DNA nanostructures, their interface with biological systems such as cellular uptake, intracellular fate and <em>in vivo</em> targeting of 3D DNA nanostructures. Finally, it identifies the challenges of DNA nanotechnology and paves the prospective ways for their futuristic transitions into devices in healthcare and bioengineering.</p> <p>URN:NBN:sciencein.nanomed.2022.v2.337</p>
ArticlesDNA nanodevicesin vivo deliverybiosensingtherapeuticsregenerative medicinebiomedical applicationsKrupa KansaraAshutosh KumarDhiraj Bhatia
Copyright (c) 2022 Krupa Kansara, Ashutosh Kumar, Dhiraj Bhatia
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2022-06-202022-06-20337337Aptamers functionalized biomolecular nano-vehicles for applications in cancer diagnostics & therapeutics
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/360
<p>Given its structural versatility and functional programmability, DNA has emerged as an ideal scaffold for developing nanoscale materials with emerging applications, including the ones in diagnosis and therapeutics. The two main components contributing to the successful sojourn of DNA devices in biological systems are their ability to either encapsulate or functionalize nanoparticles' diversity and their capabilities for specific physical recognitions via modules like targeting entities like aptamers. DNA-based nanoparticles and aptamers functionalized DNA nanodevices enable high biocompatibility, biological targeting, stability, and drug loading. As a result, they have seen their enhanced usage in biomedical applications. This review presents an overall picture and current trends of lipid & non-lipid-based nano-vehicles that can be functionalized with aptamers and loaded for applications like bio-sensing and delivery, especially focusing on cancer diagnosis therapeutics. We conclude with future prospective and directions for improving current systems to interface with biological systems and upgrade materials for clinical transition.<strong> </strong></p> <p>URN:NBN:sciencein.nanomed.2022.v2.360</p>
ArticlesCanceraptamersnanoparticlesaptasensorsDrug deliverygene therapySreyashi DasArushi GuptaVaishnavi T VShanka WaliaDhiraj BhatiaBanani Chakraborty
Copyright (c) 2022 Sreyashi Das, Arushi Gupta, Vaishnavi T V, Shanka Walia, Dhiraj Bhatia, Banani Chakraborty
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2022-06-012022-06-01360360Nanotherapeutics and HIV: Four decades of infection canvass the quest for drug development using nanomedical technologies
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/354
<p>We have seen four decades of human struggle to cure or eradicate HIV infection since the first clinical detection of HIV infection. Various developed drugs such as nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, integrase inhibitors, microbicides, and others have known restrictions, such as side effects and resistance development when used alone, and hidden reservoir of the virus, which have opened the gates for the involvement of nanomedicine associated systems, particularly for latent sites of HIV infection. The nanotechnological vehicles, such as liposomes, dendrimers, metal nanoparticles, polymeric nanocapsules/particles, surfactants, and targeted vehicles have become part of extensive studies for application in real settings for the delivery of NRTIs, NNRTIs, microbicides, and siRNA. The positional standing of research in quest of potential therapeutics for combating HIV infection in reference for four decades with this virus need a rational evaluation of nanotechnology to achieve a practical solution to save the lives.</p> <p>urn:nbn:sciencein.nanomed.2022.v2.354</p>
EditorialAIDSDrug deliveryHIVNanobiotechnologyNanomedicinesiRNA deliveryBhupender S. ChhikaraNirpendra SinghPoonamParveen BazardRajender S. VarmaKeykavous Parang
Copyright (c) 2022 Bhupender S. Chhikara, Nirpendra Singh, Poonam, Parveen Bazard, Rajender S. Varma, Keykavous Parang
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2022-08-022022-08-02354354In-vitro antioxidant and anticancer activities of MnFe2O4 nanoparticles synthesized using spinach leaves extract
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/330
<p>Herein, MnFe<sub>2</sub>O<sub>4</sub> nanoparticles were synthesized using microwave-assisted method in the presence of spinach leaves extract. The In-house synthesized metal Mn (II) and Fe (III) 3-acetyl-coumarin metal complexes were characterized by FTIR, 1HNMR and Mass spectra. The as-synthesized nanoparticles were characterized by FTIR, XRD, FESEM and vibrating sample magnetometer. The addition of spinach leaves extract reduces the particle size more. The antioxidant activity of functionalized MnFe<sub>2</sub>O<sub>4</sub> was carried out. According to the results obtained, MnFe<sub>2</sub>O<sub>4</sub> is a potential material for antioxidant material. The free radical scavenging properties of the compounds were also examined in vitro by determining the capacity to scavenge superoxide anion formation and the interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The compounds showed a significant effect in the above tests except to scavenge superoxide anion formation. The MnFe<sub>2</sub>O<sub>4</sub> nanoparticles could be readily separated from water solution after the disinfection process by applying an external magnetic field.</p> <p>URN:NBN:sciencein.nanomed.2022.v2.330</p>
Articlesmixed metal nanoparticlesmetal oxideplant extractnanoparticle synthesisantioxidantRavikumar NaikS.A. ShivashankarP.J. Bindu
Copyright (c) 2022 Ravikumar Naik, S.A. Shivashankar, P.J. Bindu
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2022-02-202022-02-20330330RETRACTED: Selenium Nanoparticles: Synthesis using Averrhoa carambola extract, characterization and its biological applications
https://pubs.thesciencein.org/journal/index.php/nanomed/article/view/324
<p><strong>Retraction Note</strong>: This article has been marked for retraction in reference to email from corresponding author 'Dr. C. M. KAMANAVALLI' indicating the conflict of interest in publishing of this work (email dated: 17-Feb-2023: nearly one year after the publication of this work in the journal). The article has been retracted from the journal.</p> <p>Nanoparticles (NPs) help to reduce the cytotoxicity, improves targeting, enhances bioactivity and provide versatile means to control the release profile of encapsulated moiety. Biogenic method of synthesis of NPs is being preferred over the conventional chemical and physical methods due to its reduced toxicity towards the environment which uses living organisms like plants, microalgae and other microorganisms. Among different NPs, inorganic metal NPs like Ag, Au, Ce, Fe, Se, Ti and Zn have special place owing to their unique bioactivities in nanoforms. Selenium (Se) is one of the essential trace element which is incorporated into selenoproteins representing the important part of enzymatic activities. SeNPs have attracted a great deal of attention in distinctive field such as antimicrobial, antioxidant and anticancer. SeNPs constitute an attractive carrier platform for various drugs to the site of action. This study is focused on the biosynthesis of SeNPs performed with <em>Averrhoa carambola </em>leaf extract. The SeNPs were further characterized using UV-Visible spectroscopy, FTIR, SEM-EDS, zeta sizer, potential and TGA-DSC. Therapeutic activity like cell viability was evaluated against different cancer cell lines using MTT assay. This article shed light on the antibacterial, anti-oxidant, anticancer and anti-ROS property of SeNPs.</p> <p>URN:NBN:sciencein.nanomed.2022.v22.324</p>
Articlesenvironmental-friendly synthesisanti-cancerROS inhibitionnanotechnologyantioxidantMadhu Prakash GaneshkarManisha Rajendra MirjankarAnjana Thatesh GaddigalParashuram ShivappaPremakshi Hucharayappa GoderChandrappa Kamanavalli
Copyright (c) 2022 Madhu Prakash Ganeshkar, Manisha Rajendra Mirjankar, Anjana Thatesh Gaddigal, Parashuram Shivappa, Premakshi Hucharayappa Goder, Chandrappa Kamanavalli
https://creativecommons.org/licenses/by-nc-nd/4.0
2022-03-042022-03-04324324