Nanotherapeutics and HIV: Four decades of infection canvass the quest for drug development using nanomedical technologies

Nanomedicine HIV


  • Bhupender S. Chhikara University of Delhi
  • Nirpendra Singh Institute for Stem Cell Science and Regenerative Medicine
  • Poonam University of Delhi
  • Parveen Bazard University of South Florida
  • Rajender S. Varma Palacký University Olomouc
  • Keykavous Parang Chapman University


AIDS, Drug delivery, HIV, Nanobiotechnology, Nanomedicine, siRNA delivery


We have seen four decades of human struggle to cure or eradicate HIV infection since the first clinical detection of HIV infection. Various developed drugs such as nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, integrase inhibitors, microbicides, and others have known restrictions, such as side effects and resistance development when used alone, and hidden reservoir of the virus, which have opened the gates for the involvement of nanomedicine associated systems, particularly for latent sites of HIV infection. The nanotechnological vehicles, such as liposomes, dendrimers, metal nanoparticles, polymeric nanocapsules/particles, surfactants, and targeted vehicles have become part of extensive studies for application in real settings for the delivery of NRTIs, NNRTIs, microbicides, and siRNA. The positional standing of research in quest of potential therapeutics for combating HIV infection in reference for four decades with this virus need a rational evaluation of nanotechnology to achieve a practical solution to save the lives.



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Author Biography

  • Keykavous Parang, Chapman University

    Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA








How to Cite

Chhikara, B. S.; Singh, N.; Poonam; Bazard, P.; Varma, R. S.; Parang, K. Nanotherapeutics and HIV: Four Decades of Infection Canvass the Quest for Drug Development Using Nanomedical Technologies. Appl NanoMed 2022, 2 (1), 354.