Recent advances in development of Inhibitors of Dengue infection

Authors

  • Poonam Bhargava University of Delhi
  • Nisha Aggarwal University of Delhi

Abstract

Dengue virus infection is a serious threat to global health since an estimated 2.5 billion people worldwide are at risk for epidemic transmission. Dengue virus (DENV) is mosquito-borne arboviruses responsible for causing acute systemic diseases and grievous health conditions in humans. Currently, there is no vaccine available to combat dengue infection therefore; there is an urgent need to develop an efficient, specific, safe and low-cost vaccine or drug that can act against dengue virus infection. This short review discusses current and newly discovered peptidyl and non-peptidyl inhibitor scaffolds that target the DENV protease effectively.

Author Biographies

Poonam Bhargava, University of Delhi

Department of Chemistry,
Miranda House

Nisha Aggarwal, University of Delhi

Department of Chemistry

Anti-Dengue drug molecules

Published

2015-08-22

How to Cite

Bhargava, P., & Aggarwal, N. (2015). Recent advances in development of Inhibitors of Dengue infection. Chemical Biology Letters, 2(2), 22–29. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/99

Issue

Section

Review Articles