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  • Green synthesized Allium cepa nanoparticles with enhanced antiprotozoal activities for E. gingivalis

    Allium cepa has phytochemical characteristics well known to be used in our gastronomy. Due to its particle size, low systemic bioavailability is the major disadvantage associated that pose major hurdle for its use for medicinal purpose. These limitations can be overcome by converting the bulk size particles to nanosized particles. The present study was to prepare the nano-particles of Allium cepa with improved aqueous solubility, and to investigate their in-vitro efficacy against Entamoeba gingivalis, a protozoan associated with poor oral hygiene leading to advanced periodontal disease. Allium cepa nanoparticles of the size ranging 85–95 nm with the aqueous solubility of upto 3 mg/mL were prepared, and the anti-amoebic activities were tested in-vitro against Entamoeba gingivalis (ATCC 30927). The trophozoites of Entamoeba gingivalis were cultured in the presence of Allium cepa’s Bulk/nano- particles or metronidazole, the inhibition caused by each particles type at various concentrations was calculated by counting the viable trophozoites under the inverted microscope. Allium cepa nanoparticles showed inhibitory results of more than 80%, which is comparable with that of standard drug Metronidazole against E. gingivalis demonstrating its use as a potential anti-parasitic herbal drug.

    Published in: Chemical Biology Letters

    Link: https://pubs.thesciencein.org/journal/index.php/cbl/article/view/246

  • Phytochemical screening, GC-MS analysis and In-vitro Antioxidant potential of Parthenium hysterophorus Stem sequentially extracted fractions

    Oxidative stress (OS) is involved in pathophysiological events of different diseases. Antioxidants mitigate and suppress the adverse effect of OS in the body. Due to lesser side effects and cost effectiveness natural antioxidant is a choice of people nowadays. The present study was designed to characterize/analyze phytochemicals and antioxidant potential in Parthenium hysterophorus (Asteraceae) stem (PHS) sequentially extracted fractions. Chemical characterization of PHS samples was carried out using Gas Chromatography-Mass Spectrometry (GC-MS) and Spectrophotometric techniques. Comparative antioxidant potential in PHS fractions was studied using in vitro antioxidant models. Thin layer chromatography (TLC) was performed to show a differential occurrence of phytochemicals in test fractions and related radical scavenging potential. PHS fractions showed differential presence of compounds. Appreciable radical scavenging, reducing power, and metal ion chelation potential was found in PHS fractions. In conclusion, P. hysterophorus stem may be considered a good source of natural antioxidant compounds.

    https://pubs.thesciencein.org/journal/index.php/cbl/article/view/162

  • Novel 5-Nitro Isatin derivatives as DNA Gyrase inhibitors: synthesis, anti-microbial evaluation, molecular docking, ADMET predictions and QSAR studies

    Novel series of 5-nitroindoline-2-ones was synthesized starting from 5-nitroindoline-2,3-dione 2 and 2-(5-nitro-2-oxoindolin-3-ylidene)hydrazine-1 carbothioamide 3. Compounds were evaluated for their antimicrobial activities. The data showed that compounds 2 and 6b have excellent antimicrobial activities against the two tested strains of G+ve bacteria Staphylococcus aureus and Streptococcus and E. coli when compared with the standards. Furthermore, in-vitro enzyme assay and molecular docking studies were performed for the compounds 2 and 6b against E. coli DNA gyrase B. Prediction of ADMET properties and QSAR study of compounds was carried out respectively.

    Published in: Chemical Biology Letters

    Link: https://pubs.thesciencein.org/journal/index.php/cbl/article/view/131

  • Design, synthesis, ADME prediction and anti-hyperglycemic evaluation of new alkoxyimino-substituted phenyl carboxylic acids as potent alpha-glucosidase inhibitors

    In an attempt to further explore the role of substituted carboxylic acid derivatives as antidiabetic agent, a series of alkoxyimino-substituted carboxylic acid derivatives (101-206) were designed, synthesized and evaluated for their inhibitory potential against a-amylase and a-glucosidase enzyme. Among all the tested compounds, 102 & 105 has displayed the most potent activity against a-glucosidase with the IC50 of 142.21±1.8 mM and 182.83±2.43 mM respectively, as compared to the standard drug acarbose (136.89±1.67 mM). Based on the inhibition percentage, the inhibition activity of 102 and 105 on a-glucosidase had higher potential than a-amylase. The mode of binding interactions between the a-glucosidase enzyme and the compound 102 was established to be uncompetitive using kinetic analysis. The predicted drug-likeness properties (Lipinski parameters and in silico ADME properties) of the compounds revealed their suitability as potential drug candidate.

    Published in: Chemical Biology Letters

    Link: https://pubs.thesciencein.org/journal/index.php/cbl/article/view/130

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  • Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice

    urn:nbn:sciencein.cbl.2019.v6.115

    Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice

    Published in: Chemical Biology Letters

    • Suman Devi Maharshi Dayanand University
    • Jagjeet Singh Maharshi Dayanand University
    • Vijay Kumar Maharshi Dayanand University
    • Vinay Malik Maharshi Dayanand University

    Keywords: histopathology, oxidative stress, kidney, lipid peroxidation, toxicology

    Abstract

    The present study investigated the effect of monocrotophos, a commonly used organophosphate pesticide exposure in the kidney tissues of the swiss albino mice. Monocrotophos was administered at the sub-lethal doses of 1.25mg/kg, 2.5 mg/kg and 5.0 mg/kg body weight for 24 hr. Monocrotophos toxicity generated oxidative stress in the mice as evidenced by significant decrease in the activities of glutathione, superoxide dismutase and catalase enzymes. The exposure increased the lipid peroxidation and protein oxidation in a dose dependent manner. Oxidative stress generation also elicited cytotoxic effects on the mice kidney which were supported by the histopathological changes like degeneration in glomerulus, bowmen’s capsule and tubules, hemorrhage, mononuclear cell infiltration, tubular cast and congested blood vessels in a dose-dependent manner. In conclusion, the study indicated that monocrotophos exposure at various doses induces significant deleterious health effects in mice kidney tissues via oxidative stress generation.

    Cite as: Devi, S., Singh, J., Kumar, V., & Malik, V. (2019). Monocrotophos induced Biochemical and Histopathological alterations in the Kidney tissues of Mice. Chemical Biology Letters, 6(2), 39-45.

    Retrieved full text from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/2

  • Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

    urn:nbn:sciencein.cbl.2019v6.107

    Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity

    Published in: Chemical Biology Letters

    • Ashish Bhatt Mewar University
    • Krishna Srivastava Shri Ramswaroop Memorial University
    • Ravi Kant Shri Ramswaroop Memorial University
    • Deepa Lakhmani Shri Ramswaroop Memorial University

    Keywords: 4-methyl-1H-isochromen-1-one, 1,1-biphenyl-4,4-diamine, Antibacterial activity, anti-microbial activity

    Abstract

    Selected novel β-lactam and thiazolidinone derivatives have been synthesized by the reaction of 4-methyl-1H-isochromen-1-one with 1,1-biphenyl-4,4-diamine, followed by the reaction with substituted benzaldehyde and further by the reaction with chloroacetyl chloride (for β-lactam type) and with thioglycolic acid (for thiazolidinone type) respectively . All the compounds were characterised by 1H NMR, IR and mass spectroscopy. These compounds were screened for in-vitro antimicrobial activity against Staphylococus aureus, E. coli, Pseudomonas aeruginosa strain. Some compounds have shown very good efficacy against antibacterial strain.

    Cite as: Bhatt, A., Srivastava, K., Kant, R., & Lakhmani, D. (2019). Synthesis of novel β-lactam and thiazolidinone compounds derived from 4-methyl-1H-isochromen-1-one and their antibacterial activity. Chemical Biology Letters, 6(2), 46-54.

    Retrieved full text from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/35

  • Author Guidelines for International Biomedical Frontiers Journal

    Information for Authors for submitting articles to International Biomedical Frontiers Journal

    The Authors need to submit a single file containing all the details as described below. The supplementary data files should be submitted as a separate file. A cover letter and graphical abstract should be submitted along with manuscript as details provided below.

    Cover letter

    Authors should supply a cover letter indicating rational of their work. Cover letter should also have details of at least three reviewers (with email). Cover letter should be provided on the first step of submission in “Comments for Editor’ box.

    Graphical Abstract

    Authors need to submit a graphical abstract highlighting the contents of manuscript. The guidelines for graphical abstract preparation and submission are available on this link.

    Manuscript

    Manuscript should include Title, Author (s), Affiliation (complete name of institutions), Abstract, 5 Keywords, (other sections like Introduction, Results and discussion, conclusion, experimental procedures in the main body text of manuscript could be used for full paper article), acknowledgment and references in the listed order. Short communications need not to be arranged in different sections.

    Bibliography

    The journal accept all type of citation styles. Authors may use any of the available numbered style, but are highly encouraged to use ‘Citation Manager’ program (mendeley etc.) for citation of references. The editorial office will format the references in required format.

    References should be formatted as shown for articles,1 theses,2 books,3,4 and patents,5

    1. R. Ping, M. Laura, P.S. Mario. Title of the journal article should be included here. Int. Lett.Org. Chem. 1996, 61, 4439–4449.

    2. B.K. Sharma. Ph.D. Dissertation, Thesis Title, Cornell University, 1995.

    3. R. Hussain, D. Shinkoi. Title of book like Synthesis and application of ionic liquid, John Wiley & Sons: New York, 2010.

    4. R.S. Buchanod, D.K. Reddy. In Selective Organic Transformations; T.R. Thyagarajan, Ed.; Integrated science: New York, 2002; Vol. 2, pp 1–95.

    5. G.L. Loyale, U.S. Patent 5 934 456, 1998; Chem. Abstr. 1998, 65, 2870.

    Citation Manager style files: Authors are highly encouraged to use the citation manager programs for citing and formatting the references. Authors may use Mendelay, Zotero, Paper 2 or Endnote program. If you are using any of these citation manager program for Bibliography (References and Notes), then you can download citation style file for journal (common for all ScienceIn journals):

    Mendelay, Zotero, Paper 2 style file: ScienceIn Journals CSL style file

    Authors can directly add the styles to Zotero and Mendeley, follow the below steps:
    Zotero: Open Zotero desktop > Edit (top menu)> Preferences > Cite (menu in new opened small window) > Get additional styles.. (click this link below the list of styles) > in new opened window – search the term ‘Integrated Science’ in search box and then click on ‘Integrated Science Publishing Journals’ link > style file will download > Open the file with Zotero desktop and use (this style is common for all ScienceIn Journals).
    Mendeley: Open Mendeley desktop > View (top menu) > Citation Styles > More styles.. > go to tab ‘Get more styles’ (in new opened window) > search for the term ‘Integrated Science’ in search box and then click on ‘install’ adjacent to ‘Integrated Science Publishing Journals’ list > style file will be installed > then click on ‘Use this style’ from the installed styles tab and use (this style is common for all ScienceIn Journals).

    Endnote style file: ScienceIn Journals Endnote style file

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    Also the user can check the respective program user guide (online link on Zotero, Mendeley or Endnote) regarding information on how to use the style file.

    Submission

    Authors need to submit all manuscripts through journal website. Register by following link ‘Register’ above (make sure to mark checked the options Author and reviewer while registering for journal). On login, you will find ‘new submission’ link in your panel page.

    For review purpose, author can submit the manuscript as outlined above. However, Authors are advised to prepare their manuscript according to journal article template (provided below) as it progress towards acceptance. On acceptance of manuscript, authors must need to supply their manuscript in Article template (if they have not already submitted in template). If you face difficulty in preparing manuscript according to template, then you can forward your manuscript (place all figures with caption in the end of file) to Copyeditor/Support department ( pubs@thesciencein.org )

    Templates

    On acceptance of manuscript, Authors are required to submit revised manuscript in journal articles template (If authors wish, they are free to submit their manuscript in journal article template while submitting first time).

    Biomed Frontier_Word2007-2010_template  click to download from google drive

    Instructions for conversion of manuscript in journal article template is provided on https://pubs.thesciencein.org/manuscript-conversion-in-journal-article-template-instructions/  (please check the video on the link for correctly formatting your manuscript.

    download the template (as per the MS Word version that you have on your computer), double click the file to open and then prepare your article and save it with your own name.

    Login and submit the manuscript online (submission by email are not accepted). Only online submissions are accepted now.

    Authors are advised to contact Support, Biomed Frontiers (email: pubs @ thesciencein.org ) if there is any problem in registration or submission.

    Declaration of Conflict of Interest

    Authors should mention any conflict of interest in the work submitted to Biomedical Frontiers. The statement about conflict of interest may be mentioned in the ‘Letter to editor’ or placed in the manuscript after acknowledgement section.

    Ethical Uses Declaration:

    If the manuscript report the experimentation on animals (including clinical trials on human beings), then declaration about ethical way handling of animals and about keeping the complete privacy of human identity (in case of clinical trials) must be mentioned in the manuscript.

    Helsinki Declaration (contents from NIH-NLM): When reporting experiments on human subjects, authors should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). If doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain the rationale for their approach, and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. When reporting experiments on animals, authors should be asked to indicate whether the institutional and national guide for the care and use of laboratory animals was followed.

    Submission:

    Submit manuscript on journal editorial processing site at

    https://pubs.thesciencein.org/journal/index.php/biomed

  • Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3

    urn:nbn:sciencein.cbl.2019v6.113

    Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3

    Published in Chemical Biology Letters

    • Pooja FNU University of Delhi
    • Nimisha Sinha University of Delhi
    • Sonu Kumar University of Delhi
    • Atul FNU University of Delhi
    • Sumit Kumar University of Delhi
    • Prashant Kumar SRM University
    • Abhishek Pandey University of Delhi
    • Pragya Sharma University of Delhi
    • Vithika Aggarwal University of Delhi
    • Poonam FNU University of Delhi
    • Poonam Mothsra University of Delhi
    • Brajendra Kumar Singh University of Delhi
    • Rishi Pal Singh University of Delhi
    • Yogesh Kumar University of Delhi

    Keywords: Apoptotic inducer activity, anti-cancer, anti-tumor, breast cancer, enzyme inhibition, medicinal chemistry

    Abstract

    Coumarin, triazoles and thiazolidinones are one of the most preferred and high valued scaffolds frequently used in medicinal chemistry. The synthesis of newly designed coumarin based triazolyl-thiazolidinones was performed and new compounds were obtained in good yields. The listed compounds were evaluated for their apoptotic activity and determined the minimal inhibitory concentrations for each of the compound on SCC-4 cells using MTT viability test. Furthermore, apoptotic inducer activity was assayed by detecting the expression of caspase-3, a key apoptotic enzyme.

    Cite as: FNU, P., Sinha, N., Kumar, S., FNU, A., Kumar, S., Kumar, P., Pandey, A., Sharma, P., Aggarwal, V., FNU, P., Mothsra, P., Singh, B., Singh, R., & Kumar, Y. (2019). Synthesis of coumarin based triazolyl thiazolidinones and their apoptotic inducer activity against caspase-3. Chemical Biology Letters, 6(2), 30-38.

    Retrieved full text from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/3