Aptamers functionalized biomolecular nano-vehicles for applications in cancer diagnostics & therapeutics

Aptamer in cancer therapy

Authors

  • Sreyashi Das Indian Institute of Technology Kanpur
  • Arushi Gupta Indian Institute of Science
  • Vaishnavi T V Indian Institute of Science
  • Shanka Walia Indian Institute of Technology Gandhinagar
  • Dhiraj Bhatia Indian Institute of Technology Gandhinagar
  • Banani Chakraborty Indian Institute of Science

Keywords:

Cancer, aptamers, nanoparticles, aptasensors, Drug delivery, gene therapy

Abstract

Given its structural versatility and functional programmability, DNA has emerged as an ideal scaffold for developing nanoscale materials with emerging applications, including the ones in diagnosis and therapeutics. The two main components contributing to the successful sojourn of DNA devices in biological systems are their ability to either encapsulate or functionalize nanoparticles' diversity and their capabilities for specific physical recognitions via modules like targeting entities like aptamers. DNA-based nanoparticles and aptamers functionalized DNA nanodevices enable high biocompatibility, biological targeting, stability, and drug loading. As a result, they have seen their enhanced usage in biomedical applications. This review presents an overall picture and current trends of lipid  & non-lipid-based nano-vehicles that can be functionalized with aptamers and loaded for applications like bio-sensing and delivery, especially focusing on cancer diagnosis therapeutics. We conclude with future prospective and directions for improving current systems to interface with biological systems and upgrade materials for clinical transition. 

URN:NBN:sciencein.nanomed.2022.v2.360

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Author Biographies

  • Dhiraj Bhatia, Indian Institute of Technology Gandhinagar

    Center for Biomedical Engineering

  • Banani Chakraborty, Indian Institute of Science

    Department of Chemical Engineering

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Published

2022-06-01

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Articles

URN

How to Cite

(1)
Das, S.; Gupta, A.; T V, V.; Walia, S.; Bhatia, D.; Chakraborty, B. Aptamers Functionalized Biomolecular Nano-Vehicles for Applications in Cancer Diagnostics & Therapeutics. Appl NanoMed 2022, 2 (2), 360.