Epitope-based Vaccine development: A detailed overview from in-silico vaccine design to wet lab validation

Reverse Vaccinology Epitop based

Authors

  • Vaishali Ahlawat Maharshi Dayanand University
  • Mehak Dangi Maharshi Dayanand University
  • Anil Kumar Chhillar Maharshi Dayanand University, Rohtak, Haryana, India

DOI:

https://doi.org/10.62110/sciencein.cbl.2024.v11.675

Keywords:

Epitope, Immuno-informatics, Vaccine, Subtractive Proteomics, Reverse Vaccinology

Abstract

In-silico epitope-based vaccine is the cornerstone of modern vaccine development and is illuminating by a growing number of experimental and computational methods. The reverse vaccinology approach uses computational screening of the whole proteome of a pathogen to identify the proteins with the attributes of potential vaccine targets. The selection of the right components [antigenic determinants, linkers, and intramolecular adjuvants] results in the development of a multi-epitope vaccine construct with maximum efficacy and minimum adverse effects. We provide insight into the recent advancement in epitope-based vaccines and the procedure to design the modern or next-generation vaccine. The synergy between the computational screening of vaccine candidates and experimental verification to assess the immunogenic potential improves decision-making and reduces the cost and time of the development of new therapeutics

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Author Biographies

  • Vaishali Ahlawat, Maharshi Dayanand University

    Centre for Biotechnology

  • Mehak Dangi, Maharshi Dayanand University

    Centre for Bioinformatics

  • Anil Kumar Chhillar, Maharshi Dayanand University, Rohtak, Haryana, India

    Centre for Biotechnology

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Published

2024-08-09

Issue

Section

Review Articles

URN

How to Cite

(1)
Ahlawat, V.; Dangi, M.; Chhillar, A. K. Epitope-Based Vaccine Development: A Detailed Overview from in-Silico Vaccine Design to Wet Lab Validation. Chem Biol Lett 2024, 11 (4), 675. https://doi.org/10.62110/sciencein.cbl.2024.v11.675.

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